2022
Sex differences in default mode network connectivity in healthy aging adults
Ficek-Tani B, Horien C, Ju S, Xu W, Li N, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in default mode network connectivity in healthy aging adults. Cerebral Cortex 2022, 33: 6139-6151. PMID: 36563018, PMCID: PMC10183749, DOI: 10.1093/cercor/bhac491.Peer-Reviewed Original ResearchConceptsDefault mode networkPreclinical Alzheimer's diseaseAlzheimer's diseaseSex differencesBrain connectivity changesDefault mode network connectivityIntrinsic connectivity distributionSeed-based analysisMode network connectivityMedial prefrontal cortexPosterior DMN nodesHealthy aging adultsImpact of sexLifetime riskDMN connectivityWhole brainPosterior cingulateDMN nodesSignificant sex differencesPrefrontal cortexConnectivity changesAging AdultsHealthy participantsDMN functionMode network
2020
Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases
Mormino EC, Toueg TN, Azevedo C, Castillo JB, Guo W, Nadiadwala A, Corso NK, Hall JN, Fan A, Trelle AN, Harrison MB, Hunt MP, Sha SJ, Deutsch G, James M, Fredericks CA, Koran ME, Zeineh M, Poston K, Greicius MD, Khalighi M, Davidzon GA, Shen B, Zaharchuk G, Wagner AD, Chin FT. Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 2233-2244. PMID: 32572562, PMCID: PMC7755737, DOI: 10.1007/s00259-020-04923-7.Peer-Reviewed Original ResearchConceptsStandardized uptake value ratioAlzheimer's diseaseHealthy controlsCourse of ADSemantic variant primary progressive aphasiaVariant primary progressive aphasiaNeurofibrillary tangle pathologyOlder healthy controlsUptake value ratioPrimary progressive aphasiaAnterior temporal poleMedial temporal lobeNovel PET ligandMethodsForty-nine participantsTangle pathologyTau-PETSvPPA patientsFocal uptakeEarly diagnosisSubtle elevationRobust elevationTemporal lobeHC groupProgressive aphasiaPET ligand
2019
Relative preservation of facial expression recognition in posterior cortical atrophy.
Pressman PS, Gola K, Shdo SM, Miller BL, Fredericks C, Mielke C, Pelak V, Rankin KP. Relative preservation of facial expression recognition in posterior cortical atrophy. Neurology 2019, 92: e1064-e1071. PMID: 30760634, PMCID: PMC6442010, DOI: 10.1212/wnl.0000000000007075.Peer-Reviewed Original ResearchConceptsPosterior cortical atrophyBehavioral variant frontotemporal dementiaAlzheimer's diseaseCortical atrophyHealthy controlsVariant frontotemporal dementiaObservational studyRelative preservationAffective blindsightBvFTD groupFrontotemporal dementiaPatientsGroup differencesAtrophyGroupDementiaDisease
2012
Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala–anterior paralimbic neural system
Blond BN, Fredericks CA, Blumberg HP. Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala–anterior paralimbic neural system. Bipolar Disorders 2012, 14: 340-355. PMID: 22631619, PMCID: PMC3880745, DOI: 10.1111/j.1399-5618.2012.01015.x.Peer-Reviewed Original Research