2024
Trauma‐Focused Cognitive‐Behavioral Therapy for Adolescents Bullied Because of Weight: A Feasibility Study
Lydecker J, Ozbardakci E, Lou R, Grilo C. Trauma‐Focused Cognitive‐Behavioral Therapy for Adolescents Bullied Because of Weight: A Feasibility Study. International Journal Of Eating Disorders 2024, 57: 2117-2127. PMID: 39007703, DOI: 10.1002/eat.24257.Peer-Reviewed Original ResearchCognitive-behavioral therapyTraumatic stressClinically-meaningful improvementsTrauma-focused cognitive behavioral therapyTrauma-focused cognitive-behavioral therapyPatient outcomesOvervaluation of weight/shapeSymptoms of traumatic stressWeight-related bullyingCognitive behavioral therapyCognitive-behavioralTrauma-focusedWithin-subject improvementIntrusive symptomsBehavioral therapyDietary restraintEating disordersTherapyTreatment satisfactionFunctional impairmentTreatment feasibilityAdolescentsPatientsWeight/shapeFeasibility trialNeural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge‐Eating Disorder
Chao A, Agarwal K, Zhou Y, Grilo C, Gur R, Joseph P, Shinohara R, Richmond T, Wadden T. Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge‐Eating Disorder. International Journal Of Eating Disorders 2024, 57: 1911-1923. PMID: 38953334, PMCID: PMC11483217, DOI: 10.1002/eat.24244.Peer-Reviewed Original ResearchCognitive behavioral therapyFunctional magnetic resonance imagingBlood oxygen level-dependentWait-list controlBinge-eating disorderBehavioral therapyFunctional magnetic resonance imaging sessionNeutral-relaxing cuesReward-based eating driveReward-related regionsReducing binge eatingMeasured BOLD responsesReward regionsBinge eatingBinge-eating episodesFood cuesEating drivePersonalized scriptsBOLD responseRandomized controlled trialsNeural responsesFood-stimuliBinge-eatingCuesMagnetic resonance imaging
2023
Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Grilo C, Lydecker J, Gueorguieva R. Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial. International Journal Of Eating Disorders 2023, 56: 1544-1553. PMID: 37144325, PMCID: PMC10524840, DOI: 10.1002/eat.23975.Peer-Reviewed Original ResearchConceptsInitial acute treatmentBinge-eating disorderCognitive behavioral therapyAcute treatmentBinge-eating frequencyInitial interventionTherapist-led cognitive behavioural therapyInitial pharmacological treatmentTreat remission ratesEvidence-based treatmentsSingle-site trialAcute efficacyRemission rateAdult patientsInitial treatmentPharmacological treatmentPatientsPosttreatment assessmentBehavioral treatmentSufficient benefitTherapyDisordersInterventionTreatmentPharmacotherapy
2022
Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy
Forrest L, Franko D, Thompson‐Brenner H, Grilo C. Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy. International Journal Of Eating Disorders 2022, 56: 944-955. PMID: 36565241, PMCID: PMC10159900, DOI: 10.1002/eat.23883.Peer-Reviewed Original ResearchConceptsBinge-eating disorderCognitive behavioral therapyEvidence-based treatmentsInterpersonal psychotherapyIntervention targetsBinge-eating disorder symptomsBehavioral therapyIndicator of remissionShape concernsRefinement of treatmentClinical utilityFrequent associationClinical implicationsSymptomsSymptom interactionsTherapyInterpersonal therapyWeight concernsDisorder symptomsSymptom relationshipsDisordersPatientsTreatmentSizeable minorityNetwork of symptoms
2017
Correlates of weight-related quality of life among individuals with binge eating disorder before and after cognitive behavioral therapy
Mason TB, Crosby RD, Kolotkin RL, Grilo CM, Mitchell JE, Wonderlich SA, Crow SJ, Peterson CB. Correlates of weight-related quality of life among individuals with binge eating disorder before and after cognitive behavioral therapy. Eating Behaviors 2017, 27: 1-6. PMID: 28843136, PMCID: PMC5700842, DOI: 10.1016/j.eatbeh.2017.08.001.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyED psychopathologyBody mass indexWeight-related qualityBehavioral therapyEnd of treatmentSelf-report measuresPhysical functionSubjective bingeDisorder psychopathologyPublic distressPsychosocial variablesLongitudinal associationsPsychosocial factorsPsychopathologyNumber of EDsCopingBingeCurrent studyMass indexAvailable treatmentsDistressPredictor variablesFollowing associationsWeight lossPsychological and Behavioral Treatments for Binge-Eating Disorder.
Grilo CM. Psychological and Behavioral Treatments for Binge-Eating Disorder. The Journal Of Clinical Psychiatry 2017, 78 Suppl 1: 20-24. PMID: 28125175, DOI: 10.4088/jcp.sh16003su1c.04.Peer-Reviewed Original ResearchConceptsBinge-eating disorderBehavioral treatmentBehavioral weight loss therapyCognitive behavioral therapyBinge Eating DisorderBehavioral treatment optionsInterpersonal psychotherapyIntervention protocolBetter outcomesSignificant predictorsWeight lossModest weight lossWeight loss therapyBody shapeReliable predictorTreatment outcomesLoss therapyTreatment optionsDisordersInterventionModeratorPredictorsPsychotherapyPatientsTherapy
2016
Binge abstinence is associated with reduced energy intake after treatment in patients with binge eating disorder and obesity
Masheb RM, Dorflinger LM, Rolls BJ, Mitchell DC, Grilo CM. Binge abstinence is associated with reduced energy intake after treatment in patients with binge eating disorder and obesity. Obesity 2016, 24: 2491-2496. PMID: 27797154, PMCID: PMC5172456, DOI: 10.1002/oby.21664.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPsychological functioningBinge abstinencePsychological outcomesCombination of CBTBehavioral therapyBingeRecall interviewsFunctioningAbstinence ratesDietary recall interviewsReduced energy intakeAbstinenceSignificant reductionWeight statusPsychiatric morbidityGreater improvementAdult patientsDietary counselingFruit intakeSugar intakeEnergy intakeDisordersAbstinentComplete cessation[PP.13.07] HYPERTENSION AND CARDIOVASCULAR DISEASE RISK REDUCTION IN OBESE PATIENTS WITH BINGE EATING DISORDER
Grilo C. [PP.13.07] HYPERTENSION AND CARDIOVASCULAR DISEASE RISK REDUCTION IN OBESE PATIENTS WITH BINGE EATING DISORDER. Journal Of Hypertension 2016, 34: e192-e193. DOI: 10.1097/01.hjh.0000491879.94394.fc.Peer-Reviewed Original ResearchBinge-eating disorderAnti-obesity medicationsCVD risk factorsObese patientsBlood pressureMetabolic syndromeCardiovascular disease risk reductionStepped-care treatmentSubgroup of patientsDisease risk reductionMental Health SurveyObese BED patientsBinge Eating DisorderCognitive behavioral therapyOverall significant decreaseMedical comorbiditiesRemission rateRisk factorsInitial respondersHealth SurveyHeart rateBED patientsHypertensionMixed model analysisPatientsCombining Pharmacological and Psychological Treatments for Binge Eating Disorder: Current Status, Limitations, and Future Directions
Grilo CM, Reas DL, Mitchell JE. Combining Pharmacological and Psychological Treatments for Binge Eating Disorder: Current Status, Limitations, and Future Directions. Current Psychiatry Reports 2016, 18: 55. PMID: 27086316, DOI: 10.1007/s11920-016-0696-z.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBinge Eating DisorderFuture treatment researchPsychological treatmentBehavioral therapyRecurrent bingeEating DisordersCompensatory behaviorsTreatment researchPharmacological treatmentHeightened levelsBehavioral weight loss interventionFuture researchWeight loss interventionLimited researchCurrent clinical practiceBingeCertain medicationsLoss interventionFuture directionsBWLClinical practiceWeight controlDisordersSuperior outcomes
2015
Predicting Meaningful Outcomes to Medication and Self-Help Treatments for Binge-Eating Disorder in Primary Care: The Significance of Early Rapid Response
Grilo CM, White MA, Masheb RM, Gueorguieva R. Predicting Meaningful Outcomes to Medication and Self-Help Treatments for Binge-Eating Disorder in Primary Care: The Significance of Early Rapid Response. Journal Of Consulting And Clinical Psychology 2015, 83: 387-394. PMID: 25622201, PMCID: PMC4380674, DOI: 10.1037/a0038635.Peer-Reviewed Original ResearchConceptsBinge-eating disorderSelf-help cognitive behavioral therapyPrimary care settingObese patientsFourth treatment weekBaseline clinical characteristicsBetter clinical outcomesPrimary care physiciansObese patient groupRandomized clinical trialsStrong prognostic indicatorSelf-help interventionEating-disorder psychopathologyImportant clinical implicationsCognitive behavioral therapyAntiobesity medicationsClinical characteristicsMixed-effects model analysisClinical outcomesPercent weight lossPatient groupPrognostic indicatorTreatment weekClinical trialsResearch clinicians
2014
Current and emerging drug treatments for binge eating disorder
Reas DL, Grilo CM. Current and emerging drug treatments for binge eating disorder. Expert Opinion On Emerging Drugs 2014, 19: 99-142. PMID: 24460483, PMCID: PMC4026932, DOI: 10.1517/14728214.2014.879291.Peer-Reviewed Original ResearchConceptsPsychological interventionsDisorder psychopathologyWeight lossCognitive behavioral therapyCertain medicationsBinge Eating DisorderBehavioral weight lossCombination of medicationsEating DisordersBingeDrug treatmentLong-term effectsMedicationsAssociated depressionTreatment studiesPsychopathologyBED outcomesPhase IIInterventionOutcomesDepressionTrialsDisordersRemissionPharmacotherapy
2013
Self-help for binge eating disorder in primary care: A randomized controlled trial with ethnically and racially diverse obese patients
Grilo CM, White MA, Gueorguieva R, Barnes RD, Masheb RM. Self-help for binge eating disorder in primary care: A randomized controlled trial with ethnically and racially diverse obese patients. Behaviour Research And Therapy 2013, 51: 855-861. PMID: 24189569, PMCID: PMC3863907, DOI: 10.1016/j.brat.2013.10.002.Peer-Reviewed Original ResearchConceptsDiverse obese patientsUsual careObese patientsSelf-help CBTPrimary careEating Disorder ExaminationPrimary care interventionsPrimary care settingSelf-help versionFour-month treatmentSelf-help treatmentFront-line interventionCognitive behavioral therapyRemission rateMixed modelsCare interventionsCare settingsPatientsGeneralist settingsBehavioral therapyDisorder ExaminationDisorder psychopathologyWeight lossBingeCare
2011
Cognitive–Behavioral Therapy, Behavioral Weight Loss, and Sequential Treatment for Obese Patients With Binge-Eating Disorder: A Randomized Controlled Trial
Grilo CM, Masheb RM, Wilson GT, Gueorguieva R, White MA. Cognitive–Behavioral Therapy, Behavioral Weight Loss, and Sequential Treatment for Obese Patients With Binge-Eating Disorder: A Randomized Controlled Trial. Journal Of Consulting And Clinical Psychology 2011, 79: 675-685. PMID: 21859185, PMCID: PMC3258572, DOI: 10.1037/a0025049.Peer-Reviewed Original ResearchConceptsPercent BMI lossBehavioral weight lossBinge-eating disorderCognitive behavioral therapyBMI lossObese patientsWeight lossBinge-eating remissionAlternative treatment optionBinge Eating DisorderRemission rateControlled TrialsTreatment optionsMixed model analysisBehavioral therapyPatientsManualized treatmentAssessment pointsBingeRemissionGreater reductionTreatmentTherapySequential treatmentDisordersA randomized controlled trial for obesity and binge eating disorder: Low-energy-density dietary counseling and cognitive-behavioral therapy
Masheb RM, Grilo CM, Rolls BJ. A randomized controlled trial for obesity and binge eating disorder: Low-energy-density dietary counseling and cognitive-behavioral therapy. Behaviour Research And Therapy 2011, 49: 821-829. PMID: 22005587, PMCID: PMC3223390, DOI: 10.1016/j.brat.2011.09.006.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyWeight lossDietary counselingVegetable consumptionPercent of participantsBinge remissionObese patientsRemission outcomesNutrition counselingMetabolic outcomesObese individualsConsecutive participantsFavorable outcomeDietary outcomesTwelve-monthBetter dietary outcomesDensity dietIndividual treatmentTreatment effectsOutcomesTherapyCounselingTreatmentBingeDisorders
2005
A randomized controlled comparison of guided self-help cognitive behavioral therapy and behavioral weight loss for binge eating disorder
Grilo CM, Masheb RM. A randomized controlled comparison of guided self-help cognitive behavioral therapy and behavioral weight loss for binge eating disorder. Behaviour Research And Therapy 2005, 43: 1509-1525. PMID: 16159592, DOI: 10.1016/j.brat.2004.11.010.Peer-Reviewed Original ResearchConceptsSelf-help cognitive behavioral therapyCognitive behavioral therapyWeight lossConsecutive overweight patientsHigher remission ratesBehavioral weight lossTreatment of BEDOverweight patientsRemission rateTreat analysisMinimal therapist guidanceHigher completion ratesTherapist guidanceBehavioral therapyCBTgshControl treatment conditionsSelf-help approachTreatment treatmentNon-specific influencesRelative efficacyTreatmentCompletion ratesTherapyBingeDisordersCognitive Behavioral Therapy Guided Self-Help and Orlistat for the Treatment of Binge Eating Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
Grilo CM, Masheb RM, Salant SL. Cognitive Behavioral Therapy Guided Self-Help and Orlistat for the Treatment of Binge Eating Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial. Biological Psychiatry 2005, 57: 1193-1201. PMID: 15866560, DOI: 10.1016/j.biopsych.2005.03.001.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyWeight lossSelf-help cognitive behavioral therapyAddition of placeboFacilitate weight lossTreat remission ratesPercent of patientsDouble-blind fashionPlacebo-controlled studyAddition of orlistatGreater weight lossGuided Self-HelpObese BED patientsBinge Eating DisorderRemission rateTreatment discontinuationClinical improvementObesity medicationsBED patientsCBTgshOrlistatPlaceboBehavioral therapyDisorder psychopathologyComparable improvementEfficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: A randomized double-blind placebo-controlled comparison
Grilo CM, Masheb RM, Wilson GT. Efficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: A randomized double-blind placebo-controlled comparison. Biological Psychiatry 2005, 57: 301-309. PMID: 15691532, DOI: 10.1016/j.biopsych.2004.11.002.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBehavioral therapyEfficacy of CBTTreatment of bingeTreat remission ratesCBT conditionCognitive featuresPsychological featuresPsychological distressDimensional measuresBingeRemission rateDouble-blind placebo-controlled comparisonDouble-blind fashionPlacebo-controlled comparisonPlacebo-controlled studyConsistent findingCompletersIndividual treatmentCertain medicationsPharmacological therapyITT analysisFluoxetineDisordersPlacebo