2024
The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome
Koo B, Abdelfattah A, Eysa A, Lu L. The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome. Annals Of Neurology 2024, 95: 688-699. PMID: 38308537, DOI: 10.1002/ana.26876.Peer-Reviewed Original ResearchRestless legs syndromeRestless legs syndrome patientsRestless legs syndrome severityAdrenocorticotropin hormoneCerebrospinal fluidB-endorphinPro-opiomelanocortinA-MSHPlasma adrenocorticotropin hormoneRLS participantsInternational RLS Study Group Severity ScaleRLS patientsAssessed plasmaPain symptomsLumbar punctureA-melanocyte-stimulating hormoneMatched controlsPatientsHormoneSeverity ScaleSensory discomfortPlasmaSeverityMelanocortin hormonesHyperalgesia
2023
Can tonic motor activation be the magical elixir for restless legs syndrome?
Berkowski J, Koo B. Can tonic motor activation be the magical elixir for restless legs syndrome? Sleep 2023, 46: zsad230. PMID: 37671678, PMCID: PMC11240113, DOI: 10.1093/sleep/zsad230.Peer-Reviewed Original ResearchReview of the role of the endogenous opioid and melanocortin systems in the restless legs syndrome
Walters A, Li Y, Koo B, Ondo W, Weinstock L, Champion D, Afrin L, Karroum E, Bagai K, Spruyt K. Review of the role of the endogenous opioid and melanocortin systems in the restless legs syndrome. Brain 2023, 147: 26-38. PMID: 37633259, PMCID: PMC10796165, DOI: 10.1093/brain/awad283.Peer-Reviewed Original ResearchConceptsRestless legs syndromeMu-opioid receptorsRLS patientsEndogenous opioidsLegs syndromeOpioid receptorsSerum ironΒ-endorphinMelanocortin systemIdiopathic restless legs syndromeRLS-like symptomsPeriodic limb movementsLow serum ironWild-type miceSensory changesMelanocyte stimulating hormoneReceptor blockersSerum ferritinAutopsy studyStriatal dopamineAdrenocorticotropic hormoneStimulating hormoneDopaminergic systemMouse modelTherapeutic efficacyDifferential impact of resilience on demoralization and depression in Parkinson disease
de Figueiredo J, Zhu B, Patel A, Kohn R, Koo B, Louis E. Differential impact of resilience on demoralization and depression in Parkinson disease. Frontiers In Psychiatry 2023, 14: 1207019. PMID: 37559912, PMCID: PMC10408307, DOI: 10.3389/fpsyt.2023.1207019.Peer-Reviewed Original ResearchDevelopment and validation of a model predicting mild stroke severity on admission using electronic health record data
Waddell K, Myers L, Perkins A, Sico J, Sexson A, Burrone L, Taylor S, Koo B, Daggy J, Bravata D. Development and validation of a model predicting mild stroke severity on admission using electronic health record data. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107255. PMID: 37473533, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107255.Peer-Reviewed Original ResearchConceptsInitial stroke severityStroke severityElectronic health record dataHealth record dataSevere strokeIschemic strokeStroke careSample patientsMortality risk stratificationRecord dataVeterans Affairs hospitalMild stroke severityMultiple logistic regressionObservational cohortStroke outcomeIndependent predictorsRisk stratificationEHR data elementsPrimary analysisLogistic regressionStrokeValidation sampleSeverityPotent modifierEHR dataYou too can increase brain iron to treat restless legs syndrome
Koo B. You too can increase brain iron to treat restless legs syndrome. Sleep 2023, 46: zsad181. PMID: 37419490, DOI: 10.1093/sleep/zsad181.Peer-Reviewed Original ResearchImpact of the coronavirus disease-2019 pandemic on Veterans Health Administration Sleep Services
Sico J, Koo B, Perkins A, Burrone L, Sexson A, Myers L, Taylor S, Yarbrough W, Daggy J, Miech E, Bravata D. Impact of the coronavirus disease-2019 pandemic on Veterans Health Administration Sleep Services. SAGE Open Medicine 2023, 11: 20503121231169388. PMID: 37152838, PMCID: PMC10158800, DOI: 10.1177/20503121231169388.Peer-Reviewed Original ResearchSleep servicesCoronavirus diseaseVeterans AffairsSleep medicine providersHome sleep testingVeterans Affairs facilitiesTransmission precautionsSleep testingVideo telehealthSleep studiesMedicine providersMedicine servicePre-pandemic surveyCare deliveryMedicine personnelClinicDiagnostic studiesDiseaseHigh rateSecond surveyPandemicPandemic periodHigh levelsOnline surveySeparate surveys
2022
Re-equip with opioids instead of dopamine agonists for the treatment of augmentation
Koo B. Re-equip with opioids instead of dopamine agonists for the treatment of augmentation. Sleep 2022, 45: zsac115. PMID: 35556146, DOI: 10.1093/sleep/zsac115.Peer-Reviewed Original Research
2021
The Management of Restless Legs Syndrome: An Updated Algorithm.
Silber MH, Buchfuhrer MJ, Earley CJ, Koo BB, Manconi M, Winkelman JW. The Management of Restless Legs Syndrome: An Updated Algorithm. Mayo Clinic Proceedings 2021, 96: 1921-1937. PMID: 34218864, DOI: 10.1016/j.mayocp.2020.12.026.Peer-Reviewed Original Research
2020
Hypothyroidism in restless legs syndrome
Ahmed N, Kandil M, Elfil M, Jamal A, Koo BB. Hypothyroidism in restless legs syndrome. Journal Of Sleep Research 2020, 30: e13091. PMID: 32483857, DOI: 10.1111/jsr.13091.Peer-Reviewed Original ResearchConceptsRestless legs syndromeLegs syndromeRLS severityHigh prevalenceInternational RLS Study Group Severity ScaleHypothyroid participantsHypothyroidism prevalenceRLS FoundationRLS pathophysiologyRLS sufferersRLS prevalenceHypothyroid subjectsThyroid diseaseHypothyroidismSeverity ScalePrevalenceLine registryStudy objectiveSyndromePotential research participantsBiological mechanismsSeverityParticipantsPersonsHyperthyroidism0795 The Relationship Between Restless Legs Syndrome and Hypothyroidism
Ahmed N, Kandil M, Elfil M, Jamal A, Koo B. 0795 The Relationship Between Restless Legs Syndrome and Hypothyroidism. Sleep 2020, 43: a302-a303. DOI: 10.1093/sleep/zsaa056.791.Peer-Reviewed Original ResearchRestless legs syndromeHypothyroidism prevalenceRLS pathophysiologyRLS prevalenceLegs syndromeRLS severityInternational RLS Study Group Severity ScaleHigher RLS prevalenceCause of hypothyroidismHypothyroid participantsRLS FoundationClinical research participantsHypothyroid subjectsPhysician diagnosisControl subjectsThyroid diseaseHypothyroidismSeverity ScalePrevalenceLine registryPathophysiologySyndromeBiological mechanismsSeverityAgeImplications of Gut Microbiome Dysbiosis in Parkinson’s Disease: A Literature Review. (103)
Elfil M, Kamel S, Kandil M, Ahmed N, Schaefer S, Koo B. Implications of Gut Microbiome Dysbiosis in Parkinson’s Disease: A Literature Review. (103). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.103.Peer-Reviewed Original ResearchNeuroimaging-Guided Thrombolytic Treatment in Wake-Up Stroke: A Literature Review (127)
Elfil M, Eldokmak M, Baratloo A, Ahmed N, Amin H, Koo B. Neuroimaging-Guided Thrombolytic Treatment in Wake-Up Stroke: A Literature Review (127). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.127.Peer-Reviewed Original ResearchImplications of the Gut Microbiome in Parkinson's Disease
Elfil M, Kamel S, Kandil M, Koo BB, Schaefer SM. Implications of the Gut Microbiome in Parkinson's Disease. Movement Disorders 2020, 35: 921-933. PMID: 32092186, DOI: 10.1002/mds.28004.Peer-Reviewed Original ResearchConceptsParkinson's disease patientsDisease patientsParkinson's diseaseMotor symptomsNervous systemEnteric nervous systemGut microbiome dysbiosisGut microbiome changesDifferent body systemsRelease of neurotoxinsCentral nervous systemCommon neurodegenerative disorderNormal gut microbiomeΑ-synuclein aggregatesNonmotor manifestationsAutoimmune responseNeuroprotective factorsAutopsy studyDopaminergic neuronsSubstantia nigraPathophysiologic changesMicrobiome dysbiosisMotor featuresGastrointestinal systemSystemic circulation
2019
Association of Novel Measures of Sleep Disturbances and Blood Pressure: The MESA Study
Kim J, Azarbarzin A, Wang R, Djonlagic I, Punjabi N, Zee P, Koo B, Soliman E, Lederer D, Younes M, Redline S. Association of Novel Measures of Sleep Disturbances and Blood Pressure: The MESA Study. 2019, a7270-a7270. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7270.Peer-Reviewed Original Research0670 Sleep-Related Event Physiologic Timing for Triggering Nonsustained Ventricular Tachycardia: A Case-crossover Analysis
May A, May R, Bena J, Wang L, Monahan K, Stone K, Barrett-Connor E, Koo B, Winkelman J, Redline S, Mittleman M, Mehra R. 0670 Sleep-Related Event Physiologic Timing for Triggering Nonsustained Ventricular Tachycardia: A Case-crossover Analysis. Sleep 2019, 42: a267-a268. DOI: 10.1093/sleep/zsz067.668.Peer-Reviewed Original ResearchRespiratory eventsSleep-related eventsHazard periodOsteoporotic fracturesOdds ratioBidirectional case-crossover designPeriodic limb movementsRespiratory-related arousalsConditional logistic regressionCase-crossover analysisCase-crossover designPhysiologic timingVentricular tachycardiaNSVTNSVT episodesPhysiologic effectsPLMSOlder menStudy participantsMan studyLogistic regressionLimb movementsSleepControl periodConfidence intervalsSuicidal Behavior in Parkinson Disease (P2.8-025)
Koo B, Ahmed N, Alapati A, Bahekar R, Chilakamarri P, Elfil M, Nalamada K, SirDeshpande P, Louis E. Suicidal Behavior in Parkinson Disease (P2.8-025). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p2.8-025.Peer-Reviewed Original ResearchChapter 4 Treatment of Sleep-Related Movement and Circadian Rhythm Disorders, Hypersomnolence, and Parasomnias
Miner B, Jiwa N, Koo B. Chapter 4 Treatment of Sleep-Related Movement and Circadian Rhythm Disorders, Hypersomnolence, and Parasomnias. 2019, 77-95. DOI: 10.1016/b978-0-12-813014-8.00004-4.ChaptersSleep disordersPeriodic limb movement disorderRestless legs syndromeLimb movement disorderCircadian rhythm sleep disordersCircadian rhythm disordersPharmacologic optionsHypersomnolence disordersLegs syndromeMovement disordersRhythm disordersDisordersChapter 4 TreatmentBehavioral modificationParasomniasTreatmentPsychotherapeutic modalitiesDifferent psychotherapeutic modalitiesHypersomnolenceMedicationsSyndrome
2018
Suicidal thought and behavior in individuals with restless legs syndrome
Para KS, Chow CA, Nalamada K, Kakade VM, Chilakamarri P, Louis ED, Koo BB. Suicidal thought and behavior in individuals with restless legs syndrome. Sleep Medicine 2018, 54: 1-7. PMID: 30529070, DOI: 10.1016/j.sleep.2018.09.019.Peer-Reviewed Original ResearchConceptsRestless legs syndromeInternational RLS Study Group Severity ScaleLifetime suicidal ideationLifetime depression historySuicidal ideationDepression historyLegs syndromeControl participantsBrief Lifetime Depression ScaleCambridge-Hopkins RLS questionnairePotential demographic confoundersRisk of suicideStepwise logistic regressionRLS sufferersRLS questionnaireRLS diagnosisRLS severityDepression ScaleSuicidal Behaviors QuestionnaireLifetime depressionSeverity ScaleDemographic confoundersSuicidal thoughtsLogistic regressionDepressionRestless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis
Doan TT, Koo BB, Ogilvie RP, Redline S, Lutsey PL. Restless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis. Sleep 2018, 41: zsy106. PMID: 29860522, PMCID: PMC6093310, DOI: 10.1093/sleep/zsy106.Peer-Reviewed Original ResearchConceptsRestless legs syndromePrevalence of RLSConcurrent restless legs syndromePeriodic limb movementsMulti-Ethnic StudyLegs syndromeObesity statusOdds of RLSLimb movementsPrevalence of PLMSCommunity-based sampleRace/ethnicityRLS symptomsClinical criteriaAdjusted modelPLMSStudy participantsPrevalenceOlder individualsCross-sectional dataAtherosclerosisSexSyndromeWhite participantsSleep