2020
Implications of the Gut Microbiome in Parkinson's Disease
Elfil M, Kamel S, Kandil M, Koo BB, Schaefer SM. Implications of the Gut Microbiome in Parkinson's Disease. Movement Disorders 2020, 35: 921-933. PMID: 32092186, DOI: 10.1002/mds.28004.Peer-Reviewed Original ResearchConceptsParkinson's disease patientsDisease patientsParkinson's diseaseMotor symptomsNervous systemEnteric nervous systemGut microbiome dysbiosisGut microbiome changesDifferent body systemsRelease of neurotoxinsCentral nervous systemCommon neurodegenerative disorderNormal gut microbiomeΑ-synuclein aggregatesNonmotor manifestationsAutoimmune responseNeuroprotective factorsAutopsy studyDopaminergic neuronsSubstantia nigraPathophysiologic changesMicrobiome dysbiosisMotor featuresGastrointestinal systemSystemic circulation
2018
Demoralization in Parkinson disease
Koo BB, Chow CA, Shah DR, Khan FH, Steinberg B, Derlein D, Nalamada K, Para KS, Kakade VM, Patel AS, de Figueiredo JM, Louis ED. Demoralization in Parkinson disease. Neurology 2018, 90: e1613-e1617. PMID: 29618626, PMCID: PMC5931805, DOI: 10.1212/wnl.0000000000005425.Peer-Reviewed Original ResearchMeSH KeywordsAgedCross-Sectional StudiesDepressionFemaleHumansMaleMental HealthParkinson DiseasePrevalenceProspective StudiesSelf ConceptConceptsDisease Rating ScaleParkinson's diseasePD cohortPatient Health Questionnaire-9 scoreOutpatient movement disorder clinicYounger ageUnified Parkinson's Disease Rating ScaleParkinson's Disease Rating ScaleMovement Disorders ClinicPart III scoreStepwise logistic regressionOverall cohortMotor dysfunctionDisorders ClinicDiagnostic criteriaTreatment approachesScale scoreLogistic regressionRating ScaleCohortControl participantsMarital statusPsychosomatic researchDepressed individualsDepression