2024
The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome
Koo B, Abdelfattah A, Eysa A, Lu L. The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome. Annals Of Neurology 2024, 95: 688-699. PMID: 38308537, DOI: 10.1002/ana.26876.Peer-Reviewed Original ResearchRestless legs syndromeRestless legs syndrome patientsRestless legs syndrome severityAdrenocorticotropin hormoneCerebrospinal fluidB-endorphinPro-opiomelanocortinA-MSHPlasma adrenocorticotropin hormoneRLS participantsInternational RLS Study Group Severity ScaleRLS patientsAssessed plasmaPain symptomsLumbar punctureA-melanocyte-stimulating hormoneMatched controlsPatientsHormoneSeverity ScaleSensory discomfortPlasmaSeverityMelanocortin hormonesHyperalgesia
2023
Development and validation of a model predicting mild stroke severity on admission using electronic health record data
Waddell K, Myers L, Perkins A, Sico J, Sexson A, Burrone L, Taylor S, Koo B, Daggy J, Bravata D. Development and validation of a model predicting mild stroke severity on admission using electronic health record data. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107255. PMID: 37473533, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107255.Peer-Reviewed Original ResearchConceptsInitial stroke severityStroke severityElectronic health record dataHealth record dataSevere strokeIschemic strokeStroke careSample patientsMortality risk stratificationRecord dataVeterans Affairs hospitalMild stroke severityMultiple logistic regressionObservational cohortStroke outcomeIndependent predictorsRisk stratificationEHR data elementsPrimary analysisLogistic regressionStrokeValidation sampleSeverityPotent modifierEHR data
2020
Hypothyroidism in restless legs syndrome
Ahmed N, Kandil M, Elfil M, Jamal A, Koo BB. Hypothyroidism in restless legs syndrome. Journal Of Sleep Research 2020, 30: e13091. PMID: 32483857, DOI: 10.1111/jsr.13091.Peer-Reviewed Original ResearchConceptsRestless legs syndromeLegs syndromeRLS severityHigh prevalenceInternational RLS Study Group Severity ScaleHypothyroid participantsHypothyroidism prevalenceRLS FoundationRLS pathophysiologyRLS sufferersRLS prevalenceHypothyroid subjectsThyroid diseaseHypothyroidismSeverity ScalePrevalenceLine registryStudy objectiveSyndromePotential research participantsBiological mechanismsSeverityParticipantsPersonsHyperthyroidism0795 The Relationship Between Restless Legs Syndrome and Hypothyroidism
Ahmed N, Kandil M, Elfil M, Jamal A, Koo B. 0795 The Relationship Between Restless Legs Syndrome and Hypothyroidism. Sleep 2020, 43: a302-a303. DOI: 10.1093/sleep/zsaa056.791.Peer-Reviewed Original ResearchRestless legs syndromeHypothyroidism prevalenceRLS pathophysiologyRLS prevalenceLegs syndromeRLS severityInternational RLS Study Group Severity ScaleHigher RLS prevalenceCause of hypothyroidismHypothyroid participantsRLS FoundationClinical research participantsHypothyroid subjectsPhysician diagnosisControl subjectsThyroid diseaseHypothyroidismSeverity ScalePrevalenceLine registryPathophysiologySyndromeBiological mechanismsSeverityAge
2015
Quality measures for the care of adult patients with restless legs syndrome.
Trotti LM, Goldstein CA, Harrod CG, Koo BB, Sharon D, Zak R, Chervin RD. Quality measures for the care of adult patients with restless legs syndrome. Journal Of Clinical Sleep Medicine 2015, 11: 293-310. PMID: 25700882, PMCID: PMC4346652, DOI: 10.5664/jcsm.4550.Peer-Reviewed Original ResearchConceptsRestless legs syndromeAccuracy of diagnosisAdult patientsLegs syndromeTreatment complicationsSymptom severityCare of patientsCommon sleep disorderEvidence-based treatmentsPotential side effectsQuality measure developmentRLS managementIron storesSleep disordersControl disordersDiagnostic criteriaSide effectsBetter outcomesRoutine assessmentAmerican AcademySleep medicinePatientsOutcomesSeverityComplications
2013
Characteristics of Wake-up Stroke
Tanimoto A, Mehndiratta P, Koo BB. Characteristics of Wake-up Stroke. Journal Of Stroke And Cerebrovascular Diseases 2013, 23: 1296-1299. PMID: 24361192, DOI: 10.1016/j.jstrokecerebrovasdis.2013.10.021.Peer-Reviewed Original ResearchConceptsIschemic strokeCholesterol profileRisk factorsNon-WUS patientsStroke risk factorsDisease mechanismsWUS patientsBerlin questionnaireFrequent snoringSleep apneaMedical historyLipid profileSleep characteristicsStrokeStroke characteristicsDemographic informationPatientsAfrican AmericansQuestionnaireApneaSnoringSeverity