Ancient and continuing Darwinian selection on insulin-like growth factor II in placental fishes
O'Neill MJ, Lawton BR, Mateos M, Carone DM, Ferreri GC, Hrbek T, Meredith RW, Reznick DN, O'Neill RJ. Ancient and continuing Darwinian selection on insulin-like growth factor II in placental fishes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 12404-12409. PMID: 17636118, PMCID: PMC1941482, DOI: 10.1073/pnas.0705048104.Peer-Reviewed Original ResearchConceptsDarwinian selectionGenetic conflictPositive selectionComparative evolutionary analysisPositive Darwinian selectionNeutral mutation rateInsulin-like growth factor II geneLevel of phenotypeEvolution of placentationGrowth factor II geneRed Queen raceLevel of genesParent-offspring conflictFactor II genePlacental fishGene evolutionLivebearing fishOrder CyprinodontiformesAncient lineageGenomic imprintingStrong selectionEvolutionary analysisPlacental speciesAncient originNatural selection