2024
Using Panel Management to Identify Adult Patients With High-Risk Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis Fibrosis in a Primary Care Clinic: A Pilot Study.
Householder S, Loza A, Gupta V, Doolittle B. Using Panel Management to Identify Adult Patients With High-Risk Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis Fibrosis in a Primary Care Clinic: A Pilot Study. The Permanente Journal 2024, 1-10. PMID: 39444281, DOI: 10.7812/tpp/24.094.Peer-Reviewed Original ResearchPrimary care clinicsYears of ageCare clinicsPanel managementShear wave elastographyFIB-4 scoreElectronic health recordsDetection of patientsClinically relevant morbidityFollow-up appointmentsWave elastographyPrimary careRelevant morbidityFIB-4Advanced fibrosisFibrosis-4Adult patientsHealth recordsSubspecialty careMedical complexityExperience complicationsPatient acceptanceTargeted interventionsWork-upClinical care
2023
Crawling toward obsolescence: The extended lifespan of amylase for pancreatitis
Kanaparthy N, Loza A, Hauser R. Crawling toward obsolescence: The extended lifespan of amylase for pancreatitis. PLOS ONE 2023, 18: e0296180. PMID: 38127992, PMCID: PMC10734915, DOI: 10.1371/journal.pone.0296180.Peer-Reviewed Original ResearchAdoption of Emergency Department–Initiated Buprenorphine for Patients With Opioid Use Disorder
Gao E, Melnick E, Paek H, Nath B, Taylor R, Loza A. Adoption of Emergency Department–Initiated Buprenorphine for Patients With Opioid Use Disorder. JAMA Network Open 2023, 6: e2342786. PMID: 37948075, PMCID: PMC10638655, DOI: 10.1001/jamanetworkopen.2023.42786.Peer-Reviewed Original ResearchConceptsHealth care systemED initiationOpioid use disorderBuprenorphine initiationCare systemUse disordersEmergency Department-Initiated BuprenorphineSecondary analysisClinician's roleEmergency department initiationClinical decision support interventionClinical decision support toolProportional hazard modelingCare of patientsNetwork of cliniciansDecision support interventionsAdvanced practice practitionersDose-dependent mannerUnique cliniciansTime-dependent covariatesTrial interventionNonintervention groupED clustersMore effective interventionsNumber of exposuresPROSER: A Web-Based Peripheral Blood Smear Interpretation Support Tool Utilizing Electronic Health Record Data
Iscoe M, Loza A, Turbiville D, Campbell S, Peaper D, Balbuena-Merle R, Hauser R. PROSER: A Web-Based Peripheral Blood Smear Interpretation Support Tool Utilizing Electronic Health Record Data. American Journal Of Clinical Pathology 2023, 160: 98-105. PMID: 37026746, DOI: 10.1093/ajcp/aqad024.Peer-Reviewed Original ResearchConceptsQuality improvement studyElectronic health recordsLaboratory valuesWeb-based clinical decision support toolClinical decision support toolElectronic health record dataHealth record dataImprovement studyResident trainingBlood smear interpretationClinical outcomesMorphologic findingsAcademic hospitalCorresponding reference rangesMedication informationReference rangeMicroscopy findingsCDS toolsIntervention effectsPathology practiceSmear interpretationHealth recordsRecord dataPathologistsPatientsPredicting physician departure with machine learning on EHR use patterns: A longitudinal cohort from a large multi-specialty ambulatory practice
Lopez K, Li H, Paek H, Williams B, Nath B, Melnick E, Loza A. Predicting physician departure with machine learning on EHR use patterns: A longitudinal cohort from a large multi-specialty ambulatory practice. PLOS ONE 2023, 18: e0280251. PMID: 36724149, PMCID: PMC9891518, DOI: 10.1371/journal.pone.0280251.Peer-Reviewed Original ResearchConceptsElectronic health recordsEHR use patternsHealthcare industryPhysician departureSHAP valuesHealth recordsPhysician characteristicsLongitudinal cohortPhysician ageRisk physiciansAmbulatory practiceTargeted interventionsAppropriate interventionsPhysiciansTop variablesDocumentation timePhysician turnoverPredictive modelHeavy burdenInterventionInboxPhysician demandMachineValidatingPatients
2022
Rates of Body Mass Index Increase in Children During the COVID-19 Pandemic
Loza AJ, Child I, Doolittle BR. Rates of Body Mass Index Increase in Children During the COVID-19 Pandemic. Childhood Obesity 2022, 19: 353-356. PMID: 35904946, DOI: 10.1089/chi.2022.0047.Peer-Reviewed Original ResearchConceptsClinic visitsWeight gainRetrospective longitudinal cohort studyBody mass index increaseRegular clinic visitsSignificant public health concernPrimary care clinicsHigh-risk subgroupsLongitudinal cohort studyYears of ageCOVID-19 pandemicPublic health concernPublic health officialsCohort studyCare clinicsPediatric obesityObesity statusRisk factorsPrepandemic periodHigher baselineAge groupsBMIHealth concernStudy periodHealth officialsCollateral Damage from the COVID-19 Pandemic: Pediatric Obesity
Child I, Loza A, Doolittle B. Collateral Damage from the COVID-19 Pandemic: Pediatric Obesity. Population Health Management 2022, 25: 573-574. PMID: 35363090, DOI: 10.1089/pop.2022.0030.Peer-Reviewed Original Research
2021
Heart rate variability in patients with tetralogy of Fallot
Luna A, Church S, Loza A, Rueda-Ochoa O, Coy M, Marin C, Beach C. Heart rate variability in patients with tetralogy of Fallot. European Heart Journal 2021, 42: ehab724.1586. DOI: 10.1093/eurheartj/ehab724.1586.Peer-Reviewed Original ResearchTetralogy of FallotHeart rate variabilityLogistic regression analysisClinical outcomesHealthy controlsHRV parametersHeart rate valuesHeart rateRepair of TOFCardiac autonomic nervous system activityMaximum heart rate valuesRate variabilityAutonomic nervous system activityBody mass indexDifferent clinical outcomesDevelopment of arrhythmiasCongenital heart diseaseNervous system activityMaximum heart rateRegression analysisAverage heart rateApplication of HRVHolter monitoringMass indexBackground Heart rate variabilityThe Effect of COVID-19 Pandemic Restrictions on Lead Screening in a Primary Care Clinic
Loza AJ, Doolittle BR. The Effect of COVID-19 Pandemic Restrictions on Lead Screening in a Primary Care Clinic. Journal Of Pediatric Health Care 2021, 36: 64-70. PMID: 34120794, PMCID: PMC8139238, DOI: 10.1016/j.pedhc.2021.03.004.Peer-Reviewed Original ResearchConceptsPrimary care practicesCare practicesCOVID-19 restrictionsLead screening ratesPrimary care clinicsWell-child careCoronavirus disease 2019Quality improvement initiativesElectronic medical recordsPatient safety concernsCare clinicsRoutine careScreening ratesCOVID-19 pandemic restrictionsMedical recordsLead screeningPeak restrictionsDisease 2019Outpatient pediatricsLead exposureRisk populationsLead levelsImprovement initiativesCareLead toxicityThe second pandemic: a call to action
Doolittle BR, Loza A. The second pandemic: a call to action. Pediatric Research 2021, 91: 2-3. PMID: 33731813, PMCID: PMC7968407, DOI: 10.1038/s41390-021-01461-2.Peer-Reviewed Original Research
2020
Elevated Lipemia Index in Dark-Brown Plasma from a Bronze Baby
Koch CD, Paulson N, Vera MA, Loza A, El-Khoury JM. Elevated Lipemia Index in Dark-Brown Plasma from a Bronze Baby. Clinical Chemistry 2020, 67: 447-448. PMID: 33523217, DOI: 10.1093/clinchem/hvaa146.Peer-Reviewed Original Research
2018
Epithelial vertex models with active biochemical regulation of contractility can explain organized collective cell motility.
Koride S, Loza AJ, Sun SX. Epithelial vertex models with active biochemical regulation of contractility can explain organized collective cell motility. APL Bioengineering 2018, 2: 031906. PMID: 31069315, PMCID: PMC6324211, DOI: 10.1063/1.5023410.Peer-Reviewed Original ResearchTWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis.
Grither WR, Divine LM, Meller EH, Wilke DJ, Desai RA, Loza AJ, Zhao P, Lohrey A, Longmore GD, Fuh KC. TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis. Oncogene 2018, 37: 1714-1729. PMID: 29348456, PMCID: PMC5876071, DOI: 10.1038/s41388-017-0043-9.Peer-Reviewed Original Research
2017
Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory.
Nasrollahi S, Walter C, Loza AJ, Schimizzi GV, Longmore GD, Pathak A. Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory. Biomaterials 2017, 146: 146-155. PMID: 28918264, PMCID: PMC5659718, DOI: 10.1016/j.biomaterials.2017.09.012.Peer-Reviewed Original Research
2016
Cell density and actomyosin contractility control the organization of migrating collectives within an epithelium.
Loza AJ, Koride S, Schimizzi GV, Li B, Sun SX, Longmore GD. Cell density and actomyosin contractility control the organization of migrating collectives within an epithelium. Molecular Biology Of The Cell 2016, 27: 3459-3470. PMID: 27605707, PMCID: PMC5221580, DOI: 10.1091/mbc.E16-05-0329.Peer-Reviewed Original ResearchAJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol.
Jagannathan R, Schimizzi GV, Zhang K, Loza AJ, Yabuta N, Nojima H, Longmore GD. AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol. Molecular And Cellular Biology 2016, 36: 2526-42. PMID: 27457617, PMCID: PMC5038147, DOI: 10.1128/MCB.00136-16.Peer-Reviewed Original ResearchThe Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis.
Corsa CA, Brenot A, Grither WR, Van Hove S, Loza AJ, Zhang K, Ponik SM, Liu Y, DeNardo DG, Eliceiri KW, Keely PJ, Longmore GD. The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis. Cell Reports 2016, 15: 2510-23. PMID: 27264173, PMCID: PMC4909540, DOI: 10.1016/j.celrep.2016.05.033.Peer-Reviewed Original ResearchStromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.
Ruhland MK, Loza AJ, Capietto AH, Luo X, Knolhoff BL, Flanagan KC, Belt BA, Alspach E, Leahy K, Luo J, Schaffer A, Edwards JR, Longmore G, Faccio R, DeNardo DG, Stewart SA. Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis. Nature Communications 2016, 7: 11762. PMID: 27272654, PMCID: PMC4899869, DOI: 10.1038/ncomms11762.Peer-Reviewed Original ResearchDachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis.
Li-Villarreal N, Forbes MM, Loza AJ, Chen J, Ma T, Helde K, Moens CB, Shin J, Sawada A, Hindes AE, Dubrulle J, Schier AF, Longmore GD, Marlow FL, Solnica-Krezel L. Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis. Development (Cambridge, England) 2016, 143: 1832. PMID: 27127268, PMCID: PMC4874487, DOI: 10.1242/dev.138859.Peer-Reviewed Original ResearchStromal-Initiated Changes in the Bone Promote Metastatic Niche Development.
Luo X, Fu Y, Loza AJ, Murali B, Leahy KM, Ruhland MK, Gang M, Su X, Zamani A, Shi Y, Lavine KJ, Ornitz DM, Weilbaecher KN, Long F, Novack DV, Faccio R, Longmore GD, Stewart SA. Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development. Cell Reports 2016, 14: 82-92. PMID: 26725121, PMCID: PMC4706805, DOI: 10.1016/j.celrep.2015.12.016.Peer-Reviewed Original Research