2024
A mediation analysis framework based on variance component to remove genetic confounding effect
Dong Z, Zhao H, DeWan A. A mediation analysis framework based on variance component to remove genetic confounding effect. Journal Of Human Genetics 2024, 69: 301-309. PMID: 38528049, DOI: 10.1038/s10038-024-01232-x.Peer-Reviewed Original ResearchMediation analysis frameworkSingle nucleotide polymorphismsMediation analysisPleiotropic single nucleotide polymorphismsUK Biobank dataConfounding effectsTrait pairsBiobank dataIndividual-levelEpidemiological studiesCausal effectsGenetic signalsEstimated effectsLinear regressionNucleotide polymorphismsStandard errorData analysisGenetic correlationsPhenotypeIndirect effectsPleiotropyVariance componentsOutcomesRegression
2020
Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study
Rogne T, Solligård E, Burgess S, Brumpton BM, Paulsen J, Prescott HC, Mohus RM, Gustad LT, Mehl A, Åsvold BO, DeWan AT, Damås JK. Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study. PLOS Medicine 2020, 17: e1003413. PMID: 33196656, PMCID: PMC7668585, DOI: 10.1371/journal.pmed.1003413.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexBloodstream infectionsBSI incidenceBSI mortalityHazard ratioMass indexGeneral populationPopulation-based cohortAnalysis of patientsTerms of mortalityMendelian randomization studyTraditional epidemiological studiesMendelian randomization analysisObesity paradoxMean ageObservational studyEpidemiological studiesRandomization studyCausal associationSepsisMortalityPatientsInfectionRandomization analysis