2024
Current and Future Approaches to Pediatric Anxiety Disorder Treatment
Zugman A, Winkler A, Qamar P, Pine D. Current and Future Approaches to Pediatric Anxiety Disorder Treatment. American Journal Of Psychiatry 2024, 181: 189-200. PMID: 38425255, PMCID: PMC11256210, DOI: 10.1176/appi.ajp.20231037.Peer-Reviewed Original Research
2023
Multimodal study of the neural sources of error monitoring in adolescents and adults
Conte S, Richards J, Fox N, Valadez E, McSweeney M, Tan E, Pine D, Winkler A, Liuzzi L, Cardinale E, White L, Buzzell G. Multimodal study of the neural sources of error monitoring in adolescents and adults. Psychophysiology 2023, 60: e14336. PMID: 37212619, PMCID: PMC10524909, DOI: 10.1111/psyp.14336.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexEvent-related potentialsError monitoringGoal-directed behaviorUnderlying neural mechanismsAnterior cingulate cortexAge-related differencesPerformance monitoringTemperamental riskERN componentIndividual differencesN2 componentNeural mechanismsNeural responsesAge differencesNeural generatorsCingulate cortexNeural sourcesFunctional MRIAdult participantsMultimodal studyPatterns of activityDevelopmental changesROI analysisAdult group
2022
Translating Big Data to Clinical Outcomes in Anxiety: Potential for Multimodal Integration
Khosravi P, Zugman A, Amelio P, Winkler A, Pine D. Translating Big Data to Clinical Outcomes in Anxiety: Potential for Multimodal Integration. Current Psychiatry Reports 2022, 24: 841-851. PMID: 36469202, PMCID: PMC9931491, DOI: 10.1007/s11920-022-01385-6.Peer-Reviewed Original ResearchConceptsAnxiety disordersError Related NegativityPediatric anxiety disordersMost anxiety disordersDisorder treatment outcomesAnxious individualsNeural correlatesMultimodal integrationNeural markersGroup differencesResponse/outcomesAnxietyMultimodal dataCorrelatesTreatment responseTreatment outcomesDiverse relationsDisordersReviewThis reviewNegativityRecent FindingsRecent literatureRisk markersAdulthoodSuch workOutcomes
2021
Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group
Harrewijn A, Cardinale E, Groenewold N, Bas-Hoogendam J, Aghajani M, Hilbert K, Cardoner N, Porta-Casteràs D, Gosnell S, Salas R, Jackowski A, Pan P, Salum G, Blair K, Blair J, Hammoud M, Milad M, Burkhouse K, Phan K, Schroeder H, Strawn J, Beesdo-Baum K, Jahanshad N, Thomopoulos S, Buckner R, Nielsen J, Smoller J, Soares J, Mwangi B, Wu M, Zunta-Soares G, Assaf M, Diefenbach G, Brambilla P, Maggioni E, Hofmann D, Straube T, Andreescu C, Berta R, Tamburo E, Price R, Manfro G, Agosta F, Canu E, Cividini C, Filippi M, Kostić M, Munjiza Jovanovic A, Alberton B, Benson B, Freitag G, Filippi C, Gold A, Leibenluft E, Ringlein G, Werwath K, Zwiebel H, Zugman A, Grabe H, Van der Auwera S, Wittfeld K, Völzke H, Bülow R, Balderston N, Ernst M, Grillon C, Mujica-Parodi L, van Nieuwenhuizen H, Critchley H, Makovac E, Mancini M, Meeten F, Ottaviani C, Ball T, Fonzo G, Paulus M, Stein M, Gur R, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Harper J, Myers M, Perino M, Sylvester C, Yu Q, Lueken U, Veltman D, Thompson P, Stein D, Van der Wee N, Winkler A, Pine D. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group. Translational Psychiatry 2021, 11: 502. PMID: 34599145, PMCID: PMC8486763, DOI: 10.1038/s41398-021-01622-1.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderHealthy controlsBrain structuresMain analysisSecondary analysisAnxiety disordersMale healthy controlsVertex-wise cortical thicknessFemale healthy controlsRandom interceptGlobal brain measuresStructural magnetic resonanceCortical surface areaSubcortical brain structuresMedication useYears of educationCortical thicknessSubcortical volumesWorking GroupVentral diencephalonSmall sample sizeBrain measuresInconsistent findingsRight ventral diencephalonMale individualsRecent advances in understanding neural correlates of anxiety disorders in children and adolescents
Zugman A, Winkler A, Pine D. Recent advances in understanding neural correlates of anxiety disorders in children and adolescents. Current Opinion In Psychiatry 2021, 34: 617-623. PMID: 34475352, PMCID: PMC8490291, DOI: 10.1097/yco.0000000000000743.Peer-Reviewed Original ResearchConceptsAnxiety disordersBrain regionsMedial prefrontal cortexNeural indicesLow-level threatNeural correlatesSmall effect sizesPrefrontal cortexNeural circuitryBrain circuitryCircuitry dysfunctionBrain connectivityCommon psychiatric diagnosesFearEffect sizeMost mental illnessesStria terminalisBed nucleusAnxietyAdolescentsPsychiatric diagnosisMental illnessRecent workDisordersChildren
2020
Infant behavioral reactivity predicts change in amygdala volume 12 years later
Filippi C, Sachs J, Phillips D, Winkler A, Gold A, Leibenluft E, Pine D, Fox N. Infant behavioral reactivity predicts change in amygdala volume 12 years later. Developmental Cognitive Neuroscience 2020, 42: 100776. PMID: 32452462, PMCID: PMC7096757, DOI: 10.1016/j.dcn.2020.100776.Peer-Reviewed Original ResearchConceptsYears of ageFour-month-old infantsAmygdala volumeBrain developmentAmygdala developmentPositive reactivityBehavioral reactivityStructural imagingInfant temperamentNovel evidenceChildhoodDistinct patternsCurrent studyMiddle childhoodYearsNegative reactivityReactive temperamentTemperamental reactivityInfants
2019
Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure
Abend R, Gold A, Britton J, Michalska K, Shechner T, Sachs J, Winkler A, Leibenluft E, Averbeck B, Pine D. Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure. Biological Psychiatry 2019, 87: 916-925. PMID: 31955915, PMCID: PMC7211142, DOI: 10.1016/j.biopsych.2019.11.006.Peer-Reviewed Original ResearchConceptsSkin conductance responsesConductance responsesBrain structuresThreat conditioningPathological anxietyComparison subjectsPsychophysiological responsesLarger patient samplesPrefrontal cortical thicknessHealthy comparison subjectsStructural magnetic resonance imaging (MRI) dataThreat stimuliAnticipatory respondingExtinction paradigmStimulus typeMagnetic resonance imaging dataWide age rangeCortical thicknessPatientsNeurodevelopmental changesAnticipatory responsesTranslational advancesStructural brainAdult populationPatient samplesCombining fMRI during resting state and an attention bias task in children
Harrewijn A, Abend R, Linke J, Brotman M, Fox N, Leibenluft E, Winkler A, Pine D. Combining fMRI during resting state and an attention bias task in children. NeuroImage 2019, 205: 116301. PMID: 31639510, PMCID: PMC6911838, DOI: 10.1016/j.neuroimage.2019.116301.Peer-Reviewed Original ResearchConceptsDot-probe taskAttention bias taskFunctional connectivityThreat biasBias taskCognitive tasksDifferent attentional processesReconfiguration efficiencyTask-based fMRI dataAttentional processesAttention taskSocial reticenceTask performanceAttention stateAnxiety symptomsFMRI dataPattern of modulationPrior researchTaskIQFMRICurrent studyChildrenFunctional hierarchyNetwork changes
2017
Anxiety modulates the relation between attention-deficit/hyperactivity disorder severity and working memory-related brain activity
van der Meer D, Hoekstra P, van Rooij D, Winkler A, van Ewijk H, Heslenfeld D, Oosterlaan J, Faraone S, Franke B, Buitelaar J, Hartman C. Anxiety modulates the relation between attention-deficit/hyperactivity disorder severity and working memory-related brain activity. The World Journal Of Biological Psychiatry 2017, 19: 450-460. PMID: 28635543, PMCID: PMC5581282, DOI: 10.1080/15622975.2017.1287952.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnxietyAnxiety DisordersAttention Deficit Disorder with HyperactivityCerebellumChildCognitive DysfunctionCohort StudiesComorbidityCorpus StriatumFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMemory, Short-TermSeverity of Illness IndexThalamusYoung AdultConceptsAttention-deficit/hyperactivity disorderCo-occurring anxietyADHD severityNeural activityMemory taskAttention-deficit/hyperactivity disorder severityMemory-related brain activityPresence of ADHDVisuospatial Working Memory TaskWorking Memory TaskLevel of anxietyVSWM tasksMemory loadHyperactivity disorderTask accuracyPrevious theorisingAnxiety severityBrain activityNeurobiological heterogeneityDisorder severityAnxietyWorse performanceInformation gatingYoung adultsNeural pathways
2015
Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance‐use disorders performing a go/no‐go task
Acheson A, Tagamets M, Winkler A, Rowland L, Mathias C, Wright S, Hong L, Kochunov P, Dougherty D. Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance‐use disorders performing a go/no‐go task. Brain And Behavior 2015, 5: e00352. PMID: 26221573, PMCID: PMC4511289, DOI: 10.1002/brb3.352.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAspartic AcidBrain MappingChildCorpus StriatumExecutive FunctionFamilyFemaleGenetic Predisposition to DiseaseHumansInhibition, PsychologicalLongitudinal StudiesMagnetic Resonance ImagingMaleMotor CortexNeural PathwaysProton Magnetic Resonance SpectroscopyPsychomotor PerformanceSignal Processing, Computer-AssistedSubstance-Related DisordersWhite MatterConceptsSupplementary motor areaSubstance use disordersWhite matter integrityFamily historyFrontal white matter integrityStriatal activityDorsal striatumFrontal cortical activityCortical activitySMA activityFrontal cortical projectionsDrug use disordersDorsal striatal activitySuch family historyDorsal striatum activityCortical projectionsMotor areaElevated riskOngoing longitudinal studyUse disordersWhite matterDownstream projectionsGo/
2014
Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders
Acheson A, Wijtenburg S, Rowland L, Winkler A, Gaston F, Mathias C, Fox P, Lovallo W, Wright S, Hong L, Dougherty D, Kochunov P. Assessment of whole brain white matter integrity in youths and young adults with a family history of substance‐use disorders. Human Brain Mapping 2014, 35: 5401-5413. PMID: 24867528, PMCID: PMC4206569, DOI: 10.1002/hbm.22559.Peer-Reviewed Original ResearchConceptsSubstance use disordersLower FA valuesFamily historyUse disordersFA valuesCorona radiataWhole-brain white matter integrityYoung adultsFrontostriatal white matter tractsBrain white matter integrityFrontal white matterPosterior corona radiataAnterior corona radiataFractional anisotropy (FA) dataHigher radial diffusivitySuch family historyWhite matter tractsWhite matter integrityAge-related declineImpaired myelinationAxonal myelinationCorpus callosumGeneral populationWhite matterSignificant negative correlation