2024
Long-term impact of immediate versus deferred antiretroviral therapy on kidney health in people with HIV
Pelchen-Matthews A, Mocroft A, Ryom L, Ross M, Sharma S, Coca S, Achhra A, Cornell E, Tracy R, Phillips A, Alonso M, Toulomi G, Agan B, Medland N, Wyatt C, Group I. Long-term impact of immediate versus deferred antiretroviral therapy on kidney health in people with HIV. Kidney International 2024, 106: 136-144. PMID: 38697479, PMCID: PMC11193627, DOI: 10.1016/j.kint.2024.04.010.Peer-Reviewed Original ResearchHuman immunodeficiency virusUrine albumin/creatinine ratioDeferred antiretroviral therapyChronic kidney diseaseStrategic Timing of AntiRetroviral TreatmentAntiretroviral therapyNo significant differenceTreatment armsFollow-upAnnual rate of eGFR declineRate of eGFR declineTiming of AntiRetroviral TreatmentEarly ARTART-naive adultsCD4 cell countImmediate antiretroviral therapySignificant differenceKidney-related deathLong-term safetyKidney healthStandard of careComprehensive follow-upImmunodeficiency virusAlbumin/creatinine ratioEGFR declineAcute Hepatitis due to Primary Human Immunodeficiency Virus Infection
Elliott E, Smith D, Lipscomb J, Banini B, Meurer L, Vanderford T, Johnson J, Jain D, Achhra A. Acute Hepatitis due to Primary Human Immunodeficiency Virus Infection. Open Forum Infectious Diseases 2024, 11: ofae170. PMID: 38585186, PMCID: PMC10996125, DOI: 10.1093/ofid/ofae170.Peer-Reviewed Original ResearchHuman immunodeficiency virusHuman immunodeficiency virus infectionAcute hepatitisPrimary human immunodeficiency virus infectionConsistent with acute hepatitisPrimary human immunodeficiency virusHuman immunodeficiency virus p24 antigenAcute retroviral syndromeImmunodeficiency virus infectionSevere acute hepatitisHIV proviral DNAAcute liver diseaseP24 antigenImmunodeficiency virusLaboratory abnormalitiesSystemic manifestationsRare caseLiver diseaseProviral DNAVirus infectionLiver histopathologyHepatitisCell compartmentParenchymal cellsLiver tissue
2022
Contrasting Cases of HIV Vasculopathy Associated Fusiform Aneurysms
Kyle K, Maher M, Achhra A, Venna N. Contrasting Cases of HIV Vasculopathy Associated Fusiform Aneurysms. The Neurohospitalist 2022, 13: 69-73. PMID: 36531848, PMCID: PMC9755620, DOI: 10.1177/19418744221122863.Peer-Reviewed Original ResearchHuman immunodeficiency virusProgressive multifocal leukoencephalopathyFusiform aneurysmsAntiretroviral therapy adherenceAcquired Immunodeficiency SyndromeSpectrum of severityDevelopment of aneurysmsCerebral toxoplasmosisMultifocal leukoencephalopathyClinical courseImmunodeficiency syndromeImmunodeficiency virusTherapy adherenceVessel occlusionAneurysm formationAneurysm thrombosisIntracranial fusiform aneurysmsAneurysmsCerebral aneurysmsNine monthsFirst caseCase twoVasculopathyMoyamoyaLeukoencephalopathy