2024
Outcomes for Mechanically Ventilated Patients With Acute Myocardial Infarction Admitted to Medical vs Cardiac Intensive Care Units
Shahu A, Namburar S, Banna S, Harris A, Schenck C, Trejo-Paredes C, Thomas A, Ali T, Carnicelli A, Barnett C, Solomon M, Miller P. Outcomes for Mechanically Ventilated Patients With Acute Myocardial Infarction Admitted to Medical vs Cardiac Intensive Care Units. JACC Advances 2024, 3: 101199. PMID: 39238851, PMCID: PMC11375252, DOI: 10.1016/j.jacadv.2024.101199.Peer-Reviewed Original ResearchAcute myocardial infarctionAssociated with lower in-hospital mortalityIn-hospital mortalityLower in-hospital mortalityIntensive care unitMedical ICUPrimary diagnosis of acute myocardial infarctionMultivariable adjustmentCICU admissionInvasive mechanical ventilationVizient Clinical Data BaseBackground Acute myocardial infarctionDiagnosis of acute myocardial infarctionMultivariate logistic regressionMedical intensive care unitClinical outcomesMechanical ventilationCardiogenic shockClinical Data BaseMyocardial infarctionHospital sizeTriage of critically ill patientsMedian ventilator daysTeaching hospitalLogistic regressionTracheostomy in Patients with Acute Myocardial Infarction and Respiratory Failure
Grammatico M, Banna S, Shahu A, Gastanadui M, Jimenez J, Heck C, Arias-Olson A, Thomas A, Ali T, Miller P. Tracheostomy in Patients with Acute Myocardial Infarction and Respiratory Failure. Journal Of Intensive Care Medicine 2024, 39: 1131-1137. PMID: 38715423, DOI: 10.1177/08850666241253202.Peer-Reviewed Original ResearchDays of tracheostomyInvasive mechanical ventilationIn-hospital mortalityAcute myocardial infarctionTiming of tracheostomyRespiratory failureAntiplatelet regimensMyocardial infarctionAssociated with lower in-hospital mortalityIncidence of tracheostomyLower in-hospital mortalityProportion of patientsIncidence of patientsDiagnosis of acute myocardial infarctionDAPT interruptionTracheostomy complicationsBlood transfusionOpen tracheostomyAntiplatelet therapyMechanical ventilationMultivariable adjustmentDAPT usePrimary diagnosis of acute myocardial infarctionClinical Data BaseTracheostomyPropofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction
Thomas A, Banna S, Shahu A, Ali T, Schenck C, Patel B, Notarianni A, Phommalinh M, Kochar A, Heck C, van Diepen S, Miller P. Propofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction. American Heart Journal 2024, 272: 116-125. PMID: 38554762, DOI: 10.1016/j.ahj.2024.03.013.Peer-Reviewed Original ResearchConceptsAssociated with lower mortalityAcute myocardial infarctionInvasive mechanical ventilationLower mortalityUS national databaseClinical Data BaseMyocardial infarctionIll patient populationLength of stayCritically ill patient populationIn-hospital mortalityInverse probability treatmentOptimal induction agentInduction agentNational databaseClinical outcomesMechanical ventilationProbability treatmentPropensity weightingPatient populationRandomized trialsMortalityUtilization of propofolVentilator daysPropofol group
2023
Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction
Banna S, Schenck C, Shahu A, Thomas A, Heck C, Tangredi R, Ali T, Miller P. Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction. JACC Advances 2023, 3: 100750. PMID: 38939822, PMCID: PMC11198220, DOI: 10.1016/j.jacadv.2023.100750.Peer-Reviewed Original ResearchInvasive mechanical ventilationProton pump inhibitorsStress ulcer prophylaxisAcute myocardial infarctionUlcer prophylaxisVentilator-associated pneumoniaMyocardial infarctionVentilator daysST-segment elevation myocardial infarctionBackground Proton pump inhibitorsLess ventilator-associated pneumoniaVizient Clinical Data BaseObservation cohort studyProportion of patientsElevation myocardial infarctionMultivariable logistic regressionClostridium difficile infectionLower hospitalization costsClinical data baseCardiogenic shockHospital mortalityCohort studyMultivariate adjustmentHospitalization costsMechanical ventilation
2022
Oxygen Supplementation and Hyperoxia in Critically Ill Cardiac Patients From Pathophysiology to Clinical Practice
Thomas A, van Diepen S, Beekman R, Sinha SS, Brusca SB, Alviar CL, Jentzer J, Bohula EA, Katz JN, Shahu A, Barnett C, Morrow DA, Gilmore EJ, Solomon MA, Miller PE. Oxygen Supplementation and Hyperoxia in Critically Ill Cardiac Patients From Pathophysiology to Clinical Practice. JACC Advances 2022, 1: 100065. PMID: 36238193, PMCID: PMC9555075, DOI: 10.1016/j.jacadv.2022.100065.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOxygen supplementationIntensive care unit cliniciansHarmful hemodynamic effectsAdverse clinical outcomesIll cardiac patientsManagement of patientsAcute cardiac diseaseAcute myocardial infarctionDirect cellular toxicityCoronary vasoconstrictionPulmonary hypertensionRespiratory failureHemodynamic effectsHeart failureOxygen therapyClinical outcomesSupplemental oxygenAvailable trialsCardiac arrestMyocardial infarctionCardiac patientsCardiac diseaseClinical practiceCardiovascular systemHyperoxiaSafety and Efficacy of the Supreme Biodegradable Polymer Sirolimus-Eluting Stent in Patients With Diabetes Mellitus
Thomas A, Kereiakes D, Baumbach A, Windecker S, Pietras C, Dressler O, Issever M, Curtis M, Bertolet B, Zidar J, Smits P, Díaz V, McLaurin B, Cequier Á, Takahashi A, Cannon L, Amoroso G, Kakuta T, Saito S, Leon M, Lansky A. Safety and Efficacy of the Supreme Biodegradable Polymer Sirolimus-Eluting Stent in Patients With Diabetes Mellitus. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100033. PMID: 39132558, PMCID: PMC11307809, DOI: 10.1016/j.jscai.2022.100033.Peer-Reviewed Original ResearchTarget vessel myocardial infarctionVessel myocardial infarctionDiabetes mellitusDP-EESLesion failureIII trialsCardiac deathMyocardial infarctionBiodegradable Polymer Sirolimus-Eluting StentBiodegradable polymer sirolimus-eluting stentsTarget lesion failureTarget lesion revascularizationPercutaneous coronary interventionSirolimus-Eluting StentsLong-term inflammatory responseDiabetic subgroupsLesion revascularizationNondiabetic patientsSecondary endpointsBackground PatientsCoronary interventionPrespecified analysisComposite endpointPrimary safetyWorse outcomes