2023
Brain Networks and Adolescent Alcohol Use
Yip S, Lichenstein S, Liang Q, Chaarani B, Dager A, Pearlson G, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Martinot M, Artiges E, Nees F, Orfanos D, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner J, Smolka M, Vaidya N, Walter H, Whelan R, Schumann G, Garavan H. Brain Networks and Adolescent Alcohol Use. JAMA Psychiatry 2023, 80: 1131-1141. PMID: 37647053, PMCID: PMC10469292, DOI: 10.1001/jamapsychiatry.2023.2949.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestAlcohol use riskAlcohol misuseUse riskAlcohol use disorderMale adolescentsDisorders Identification TestSingle-site studyIntervention effortsWhole-brain patternsMean ageAlcohol use dataLeading causeMagnetic resonance imaging dataMAIN OUTCOMEReward-related processesHigh riskSeparate cohortUse disordersAlcohol consumptionCurrent severityAdolescent neurodevelopmentAlcohol use behaviorsAlcohol useAUDIT scores
2017
The effect of high-dose atorvastatin on neural activity and cognitive function
Taylor BA, Dager AD, Panza GA, Zaleski AL, Meda S, Book G, Stevens MC, Tartar S, White CM, Polk DM, Pearlson GD, Thompson PD. The effect of high-dose atorvastatin on neural activity and cognitive function. American Heart Journal 2017, 197: 166-174. PMID: 29447778, PMCID: PMC6083849, DOI: 10.1016/j.ahj.2017.10.027.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingGreater activationStroop color-word scoresHopkins Verbal Learning Test-RevisedFigural memory tasksStandard neuropsychological assessmentColor-Word scoreStandard neuropsychological testsBrain activation patternsNeuropsychological test scoresSternberg taskBrain neural activationMemory taskFMRI taskTask versionsNeuropsychological testsNeural activationNeuropsychological assessmentCognitive testingEffect of statinsCognitive functionSignificant group-time interactionNeural activityBilateral precuneusClock Test
2016
Neurobiological signatures associated with alcohol and drug use in the human adolescent brain
Silveri MM, Dager AD, Cohen-Gilbert JE, Sneider JT. Neurobiological signatures associated with alcohol and drug use in the human adolescent brain. Neuroscience & Biobehavioral Reviews 2016, 70: 244-259. PMID: 27377691, PMCID: PMC5494836, DOI: 10.1016/j.neubiorev.2016.06.042.Peer-Reviewed Original ResearchConceptsAdolescent brain developmentBrain developmentNeurobiological signatureHuman adolescent brainSubstance useInitiation of alcoholInitiation of useQuantity of useAdolescent brainAdolescent alcoholProspective InvestigationDrug usersFrontal lobeDrug useCommon alterationsMR studiesBody of workBrainSecond decadeAlterationsImportant directionMR modalitiesInitiation
2015
A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers
Worhunsky PD, Dager AD, Meda SA, Khadka S, Stevens MC, Austad CS, Raskin SA, Tennen H, Wood RM, Fallahi CR, Potenza MN, Pearlson GD. A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers. Neuropsychopharmacology 2015, 41: 1637-1647. PMID: 26514582, PMCID: PMC4832027, DOI: 10.1038/npp.2015.332.Peer-Reviewed Original ResearchConceptsAlcohol useYoung adult drinkersYoung adultsPreliminary prospective studyAdult drinkersExcessive alcohol useAlcohol use disorderFunctional network activityProspective studyUse disordersFunctional brain networksGo/No-Go taskNeurobiological alterationsDomain scoresGreater riskDaily drinksAddictive disordersDrinkersDrinking occasionsLongitudinal studyFronto-parietal circuitryBrain networks
2014
Functional magnetic resonance imaging (fMRI) response to alcohol pictures predicts subsequent transition to heavy drinking in college students
Dager AD, Anderson BM, Rosen R, Khadka S, Sawyer B, Jiantonio‐Kelly R, Austad CS, Raskin SA, Tennen H, Wood RM, Fallahi CR, Pearlson GD. Functional magnetic resonance imaging (fMRI) response to alcohol pictures predicts subsequent transition to heavy drinking in college students. Addiction 2014, 109: 585-595. PMID: 24304235, PMCID: PMC3951577, DOI: 10.1111/add.12437.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlcohol DrinkingAlcohol-Related DisordersAlcoholic BeveragesAlcoholismBinge DrinkingBrainBrain MappingCaudate NucleusCerebral CortexCuesFactor Analysis, StatisticalFemaleFunctional NeuroimagingGyrus CinguliHumansLongitudinal StudiesMagnetic Resonance ImagingMalePhotic StimulationPrefrontal CortexRisk FactorsStudentsUniversitiesYoung AdultConceptsHeavy drinkersAlcohol-related problemsBOLD responseFunctional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) responseBlood oxygen level-dependent (BOLD) responseLevel-dependent responsesSingle brain networkSubsequent heavy drinkingPictures of alcoholBaseline factorsRisk factorsModerate drinkersBilateral caudateAnterior cingulateGreater riskOrbitofrontal cortexHeavy drinkingYoung adultsDrinkersDrinking amountGroup differencesBaselineAlcohol cuesLongitudinal studyNeural responses
2012
Influence of Alcohol Use and Family History of Alcoholism on Neural Response to Alcohol Cues in College Drinkers
Dager AD, Anderson BM, Stevens MC, Pulido C, Rosen R, Jiantonio‐Kelly R, Sisante J, Raskin SA, Tennen H, Austad CS, Wood RM, Fallahi CR, Pearlson GD. Influence of Alcohol Use and Family History of Alcoholism on Neural Response to Alcohol Cues in College Drinkers. Alcohol Clinical And Experimental Research 2012, 37: e161-e171. PMID: 23078363, PMCID: PMC3548054, DOI: 10.1111/j.1530-0277.2012.01879.x.Peer-Reviewed Original ResearchConceptsAlcohol cue reactivityFamily historyHeavy drinkersCue reactivityLight drinkersHeavy drinkingMagnetic resonance imaging responseBOLD responseBlood oxygen level-dependent (BOLD) contrastAlcohol cuesVisual association regionsAlcohol use disorderAlcohol imagesFunctional magnetic resonance imaging (fMRI) responsesMedial frontal cortexGreater BOLD responseLevel-dependent contrastTemporo-parietal regionsRisk factorsFrontal cortexDorsal striatumUse disordersAnterior cingulateBeverage imagesImaging response