2016
FAT1 mutations cause a glomerulotubular nephropathy
Gee HY, Sadowski CE, Aggarwal PK, Porath JD, Yakulov TA, Schueler M, Lovric S, Ashraf S, Braun DA, Halbritter J, Fang H, Airik R, Vega-Warner V, Cho KJ, Chan TA, Morris LG, ffrench-Constant C, Allen N, McNeill H, Büscher R, Kyrieleis H, Wallot M, Gaspert A, Kistler T, Milford DV, Saleem MA, Keng WT, Alexander SI, Valentini RP, Licht C, Teh JC, Bogdanovic R, Koziell A, Bierzynska A, Soliman NA, Otto EA, Lifton RP, Holzman LB, Sibinga NE, Walz G, Tufro A, Hildebrandt F. FAT1 mutations cause a glomerulotubular nephropathy. Nature Communications 2016, 7: 10822. PMID: 26905694, PMCID: PMC4770090, DOI: 10.1038/ncomms10822.Peer-Reviewed Original ResearchConceptsSteroid-resistant nephrotic syndromeChronic kidney diseaseKnockdown of Fat1Podocyte foot process effacementTubular cell functionRenal tubular cellsFoot process effacementNephrotic syndromeNeurological involvementKidney diseaseFAT1 mutationsDisease entityPodocyte-specific deletionTubular cellsTubular ectasiaProcess effacementCell functionDecreased migrationRac1/Cdc42PathogenesisFAT1Barrier developmentKnockdownRecessive mutationsHaematuria
2014
Tubular Vascular Endothelial Growth Factor-A, Erythropoietin, and Medullary Vessels: A Trio Linked by Hypoxia
Tufro A. Tubular Vascular Endothelial Growth Factor-A, Erythropoietin, and Medullary Vessels: A Trio Linked by Hypoxia. Journal Of The American Society Of Nephrology 2014, 26: 997-998. PMID: 25385850, PMCID: PMC4413774, DOI: 10.1681/asn.2014101004.Peer-Reviewed Original Research
2005
Autocrine and paracrine functions of vascular endothelial growth factor (VEGF) in renal tubular epithelial cells
Villegas G, Lange-Sperandio B, Tufro A. Autocrine and paracrine functions of vascular endothelial growth factor (VEGF) in renal tubular epithelial cells. Kidney International 2005, 67: 449-457. PMID: 15673292, DOI: 10.1111/j.1523-1755.2005.67101.x.Peer-Reviewed Original Research