Ala F Nassar, PhD
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Senior Research Scientist
Biography
Ala F. Nassar, PhD, is a faculty member at Yale University. He has over 25 years of experience in Drug Metabolism and Preclinical Drug Development with leadership roles in both big pharma, smaller biotech firms and academics (UCONN, Brandeis and Yale). He has published more than 100 articles and chapters and holds patents in the fields of drug metabolism and bioanalytical chemistry. He leads and executes ADME-Tox experiments supporting grant projects. He was the head of the drug metabolism and bioanalytical department at Vion Pharmaceuticals, where his studies of the ADME-Tox properties of Laromustine led to a fuller, more accurate and detailed understanding of the human toxicities of the drug. He was an Ass. Professor of chemistry department and the director of Mass Spectrometry Facility at Brandeis University in Waltham, MA before coming to Yale. He has served on numerous editorial boards and is the editor of the previous edition of Drug Metabolism Handbook: Concepts and Applications and Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification. Co-editor of Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development & Manufacturing, 2010. He was honored as a guest editor of the special issue of Metabolites entitled "MS-Based Drug Metabolism in Cancer Research. 2021"
Courses Taught and Coordinated
General chemistry 161 and 162, Central Connecticut State University, Spring 2017
Advanced Mass Spectrometry course at Brandeis University, Fall 2011
Coordinated and taught graduate-level course on drug metabolism and bioanalytical chemistry at University of Connecticut, 2003, 2005, 2007 and 2011
Liquid Chromatography-Mass Spectrometry at Cambridge Healthtech Institute’s World Pharmaceutical Congress Annual Meeting, Philadelphia, PA 2005 and 2007
Drug Metabolism at Cambridge Healthtech Institute’s World Pharmaceutical Congress Annual Meeting, Philadelphia, PA 2007 and 2008
Capillary Electrophoresis-Mass Spectrometry, at Battelle Memorial Institute, Columbus, OH 1998
Education & Training
- Post Doc
- UCONN/Chemistry/Pharmacology (1996)
- PhD
- UCONN, Bioanalytical/Drug Metabolism (1995)
- Visiting Scientist
- Kyushu and Nagasaki Universities (1994)
Research
Academic Achievements and Community Involvement
Links & Media
Media
Workflow of mass cytometry analysis
Photo by Bendall SC, et al. Trends Immunol. 2012;33:323–332.A liquid sample containing cells labeled with heavy metal isotope-conjugated probes (ICPs) (a) is introduced into the nebulizer (b), where it is aerosolized. The aerosol droplets are directed into the ICP torch (c),
where the cells are vaporized, atomized, and ionized. Low-mass ions are
removed in the radiofrequency (RF) quadrupole ion guide (d), resulting in a cloud of ions enriched for the probe isotopes. The ion cloud then enters the time-of-flight (TOF) chamber (e),
where the ions are separated on the basis of their mass:charge ratio as
they accelerate toward the detector. Thus, the time-resolved detector
measures a mass spectrum (f) that represents the identity and quantity of each isotope on a per cell basis. Data are generated in .fcs format (g) and analyzed using the cloud-based Cytobank platform (h).
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Yale School of Medicine
600 west campus drive
West Haven, CT 06516
United States