2024
Disability and Recurrent Stroke Among Participants in Stroke Prevention Trials
de Havenon A, Viscoli C, Kleindorfer D, Sucharew H, Delic A, Becker C, Robinson D, Yaghi S, Li V, Lansberg M, Cramer S, Mistry E, Sarpong D, Kasner S, Kernan W, Sheth K. Disability and Recurrent Stroke Among Participants in Stroke Prevention Trials. JAMA Network Open 2024, 7: e2423677. PMID: 39028666, PMCID: PMC11259901, DOI: 10.1001/jamanetworkopen.2024.23677.Peer-Reviewed Original ResearchConceptsPrevention trialsPoststroke disabilityRecurrent stroke ratesRecurrent strokeCohort studyRate of recurrent strokeStroke Prevention TrialIncreased hazardInsulin Resistance InterventionSecondary prevention trialsBaseline disabilityAssociated with increased ratesStroke rateMain OutcomesFunctional statusResistance InterventionStudy baselineSecondary outcomesPrimary outcomeWorsening heart failureModified Rankin ScaleProfession's participationLong-term followVascular deathDisability
2023
Modelling anticoagulation and health-related quality of life in those with atrial fibrillation: a secondary analysis of AFFIRM
Stulberg E, Delic A, Zheutlin A, Steinberg B, Yaghi S, Sharma R, de Havenon A. Modelling anticoagulation and health-related quality of life in those with atrial fibrillation: a secondary analysis of AFFIRM. Clinical Research In Cardiology 2023, 113: 1200-1210. PMID: 37962572, DOI: 10.1007/s00392-023-02335-9.Peer-Reviewed Original ResearchHealth-related qualityTime-varying confoundingAtrial fibrillationTime-varying covariatesSecondary analysisSelection biasAssociation of anticoagulationAssociation of warfarinAtrial Fibrillation FollowAge-stratified analysisLife substudyWarfarin useBetter HRQoLPrimary endpointTrial qualityHigher HRQoLStudy baselineEffect modificationStratified analysisAnticoagulationHRQoLInverse probabilityFibrillationStudy periodTime points
2020
Diabetic Retinopathy and Risk of Stroke
Wong KH, Hu K, Peterson C, Sheibani N, Tsivgoulis G, Majersik JJ, de Havenon AH. Diabetic Retinopathy and Risk of Stroke. Stroke 2020, 51: 3733-3736. PMID: 33019896, PMCID: PMC7686117, DOI: 10.1161/strokeaha.120.030350.Peer-Reviewed Original ResearchConceptsBlood pressure interventionsRisk of strokeDiabetic retinopathyRandomization armIncident strokePrimary outcomePressure interventionPresence of DRCox proportional hazards modelACCORD Eye StudyRapid vision lossSubsequent stroke eventsCommon microvascular complicationCox regression modelProportional hazards modelMacrovascular complicationsMicrovascular complicationsHazard ratioEye StudyMicrovascular pathologyStroke eventsStudy baselineSerum glucoseVision lossHazards model