2020
Carbon monoxide: a critical physiological regulator sensitive to light
Oren DA, Sit DK, Goudarzi SH, Wisner KL. Carbon monoxide: a critical physiological regulator sensitive to light. Translational Psychiatry 2020, 10: 87. PMID: 32152296, PMCID: PMC7062897, DOI: 10.1038/s41398-020-0766-1.Peer-Reviewed Original ResearchConceptsHealthy female volunteersAntidepressant effectsPeripheral bloodBlood samplesFemale volunteersConfirmatory studiesPhysiological regulatorPeripheral blood samplesContinuous exposureBright light exposureCritical physiological regulatorHuman evidenceVivo modelNonseasonal depressionBlood carbon monoxideMean carbon monoxideBright white lightAdditional volunteersVolunteersPutative roleCircadian rhythmExposureBloodTherapeutic lightBright light
2015
Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus.
Romerowicz-Misielak M, Oren D, Sowa-Kucma M, Tabecka-Lonczynska A, Gilun P, Stefanczyk-Krzymowska S, Koziorowski M. Changes in melatonin synthesis parameters after carbon monoxide concentration increase in the cavernous sinus. Journal Of Physiology And Pharmacology 2015, 66: 505-14. PMID: 26348075.Peer-Reviewed Original ResearchConceptsOphthalmic venous bloodVenous bloodNocturnal melatonin riseMelatonin levelsMelatonin riseWinter seasonal affective disorderNocturnal melatonin peakSeasonal affective disorderHour infusionCavernous sinusVenous sinusesNon-physiological changesAutologous blood plasmaAffective disordersSynthesis of melatoninBright light effectsBloodAANAT protein levelsMelatonin peakProtein levelsAcute impactSinusTreatmentBlood plasmaParallel changes
2005
Circadian Phase Shifting, Alerting, and Antidepressant Effects of Bright Light Treatment
Postolache T, Oren D. Circadian Phase Shifting, Alerting, and Antidepressant Effects of Bright Light Treatment. Clinics In Sports Medicine 2005, 24: 381-413. PMID: 15892931, DOI: 10.1016/j.csm.2004.12.005.Peer-Reviewed Original Research
2004
Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings.
Epperson CN, Terman M, Terman JS, Hanusa BH, Oren DA, Peindl KS, Wisner KL. Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings. The Journal Of Clinical Psychiatry 2004, 65: 421-5. PMID: 15096083, DOI: 10.4088/jcp.v65n0319.Peer-Reviewed Original ResearchConceptsBright light therapyClinical trialsLight therapyAntepartum depressionDouble-blind placebo-controlled pilot studyPlacebo-controlled pilot studyRecent open-label studyDSM-IV major depressive disorderOpen-label studyAntidepressant drug trialsRandomized clinical trialsMajor depressive disorderAntidepressants resultsStructured interview guideActive treatmentClinical statusPregnant womenSuccessful treatmentDepressive disorderPlacebo lightDrug trialsPromising treatmentSalivary melatoninExtension phasePilot study
1998
Tweaking the human circadian clock with light.
Oren D, Terman M. Tweaking the human circadian clock with light. Science 1998, 279: 333-4. PMID: 9454328, DOI: 10.1126/science.279.5349.333.Peer-Reviewed Original Research
1997
Restoration of detectable melatonin after entrainment to a 24-hour schedule in a ‘free-running’ man
Oren D, Giesen H, Wehr T. Restoration of detectable melatonin after entrainment to a 24-hour schedule in a ‘free-running’ man. Psychoneuroendocrinology 1997, 22: 39-52. PMID: 9141150, DOI: 10.1016/s0306-4530(96)00038-8.Peer-Reviewed Original ResearchConceptsGRF-44Multiple endocrine abnormalitiesInfusion of TRHPineal gland secretionNocturnal melatonin secretionAbnormal endocrine functionCircadian rhythm disordersSleep-wake disordersGH responseThyrotropin levelsEndocrine abnormalitiesCRH infusionEndocrine challengesDifferential diagnosisAbnormal responseGonadal axesEndocrine functionRhythm disordersSerum melatoninGrowth hormoneMelatonin secretionDaily exposureCircadian profileMelatoninLux light
1995
Abnormal circadian rhythms of plasma melatonin and body temperature in the delayed sleep phase syndrome.
Oren D, Turner E, Wehr T. Abnormal circadian rhythms of plasma melatonin and body temperature in the delayed sleep phase syndrome. Journal Of Neurology Neurosurgery & Psychiatry 1995, 58: 379. PMID: 7897427, PMCID: PMC1073383, DOI: 10.1136/jnnp.58.3.379.Peer-Reviewed Original Research
1991
Retinal melatonin and dopamine in seasonal affective disorder
Oren D. Retinal melatonin and dopamine in seasonal affective disorder. Journal Of Neural Transmission 1991, 83: 85-95. PMID: 2018631, DOI: 10.1007/bf01244455.Peer-Reviewed Original Research