2010
Multicenter, randomized, double‐blind, active comparator and placebo‐controlled trial of a corticotropin‐releasing factor receptor‐1 antagonist in generalized anxiety disorder
Coric V, Feldman HH, Oren DA, Shekhar A, Pultz J, Dockens RC, Wu X, Gentile KA, Huang S, Emison E, Delmonte T, D'Souza BB, Zimbroff DL, Grebb JA, Goddard AW, Stock EG. Multicenter, randomized, double‐blind, active comparator and placebo‐controlled trial of a corticotropin‐releasing factor receptor‐1 antagonist in generalized anxiety disorder. Depression And Anxiety 2010, 27: 417-425. PMID: 20455246, DOI: 10.1002/da.20695.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnti-Anxiety AgentsAnxiety DisordersCitalopramDiagnostic and Statistical Manual of Mental DisordersDouble-Blind MethodFemaleHumansMaleMiddle AgedPharmacogeneticsPhenotypePolymorphism, Single NucleotidePsychometricsPyrazolesReceptors, Corticotropin-Releasing HormoneSeverity of Illness IndexTriazinesYoung AdultConceptsGeneralized anxiety disorderSingle nucleotide polymorphismsHamilton Anxiety Scale (HAMA) total scoreAnxiety disordersFactor receptor 1 antagonistActive comparator armCorticotropin-releasing factor receptorsActive comparator trialsPlacebo-controlled trialCorticotropin-releasing factor receptor 1 antagonistTreatment of GADPrimary outcome measurePlexin-A2Receptor 1 antagonistScale total scoreCRF-1 receptor antagonistClass of agentsComparator trialsComparator armPrimary outcomeActive comparatorEntire cohortRandomized subjectsReceptor antagonistMean change
2004
Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings.
Epperson CN, Terman M, Terman JS, Hanusa BH, Oren DA, Peindl KS, Wisner KL. Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings. The Journal Of Clinical Psychiatry 2004, 65: 421-5. PMID: 15096083, DOI: 10.4088/jcp.v65n0319.Peer-Reviewed Original ResearchMeSH KeywordsAdultCircadian RhythmDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMelatoninPhototherapyPregnancyPregnancy ComplicationsSalivaTime FactorsConceptsBright light therapyClinical trialsLight therapyAntepartum depressionDouble-blind placebo-controlled pilot studyPlacebo-controlled pilot studyRecent open-label studyDSM-IV major depressive disorderOpen-label studyAntidepressant drug trialsRandomized clinical trialsMajor depressive disorderAntidepressants resultsStructured interview guideActive treatmentClinical statusPregnant womenSuccessful treatmentDepressive disorderPlacebo lightDrug trialsPromising treatmentSalivary melatoninExtension phasePilot study