A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure
Stavres J, Luck J, Hamaoka T, Blaha C, Cauffman A, Dalton P, Herr MD, Ruiz-Velasco V, Carr Z, Janicki P, Cui J. A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure. AJP Regulatory Integrative And Comparative Physiology 2022, 323: r875-r888. PMID: 36222880, PMCID: PMC9678418, DOI: 10.1152/ajpregu.00190.2022.Peer-Reviewed Original ResearchConceptsBlood pressure indexTime-tension indexMean blood pressureBlood pressureAcid-sensing ion channelsDose of amilorideHealthy adultsOral doseIsometric plantar flexion exercisesVolume-matched placeboTotal exercise durationBlood pressure responseSingle oral doseHeart rate responsePlantar flexion exerciseBFR exerciseExercise tolerancePlacebo trialMuscle painExercise durationFlexion exercisePlantar flexionHeart ratePressure indexPain