PET measurement of the influence of corticosteroids on serotonin-1A receptor number
Montgomery A, Bench C, Young A, Hammers A, Gunn R, Bhagwagar Z, Grasby P. PET measurement of the influence of corticosteroids on serotonin-1A receptor number. Biological Psychiatry 2001, 50: 668-676. PMID: 11704073, DOI: 10.1016/s0006-3223(01)01205-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Inflammatory AgentsBinding, CompetitiveDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleFemaleHippocampusHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemReceptors, SerotoninReceptors, Serotonin, 5-HT1Tomography, Emission-ComputedConceptsPositron emission tomographyReceptor numberReceptor bindingPlacebo-controlled designInfluence of corticosteroidsSingle doseSerotonergic systemPreclinical studiesCorticosteroidsNormal subjectsModulatory effectsAlters 5Corticosteroid levelsBrain regionsEmission tomographyElevated levelsPET measurementsHippocampusHuman brainPatientsHydrocortisoneDoseBrainReceptors