2010
Increased peripheral blood expression of electron transport chain genes in bipolar depression
Beech RD, Lowthert L, Leffert JJ, Mason PN, Taylor MM, Umlauf S, Lin A, Lee JY, Maloney K, Muralidharan A, Lorberg B, Zhao H, Newton SS, Mane S, Epperson CN, Sinha R, Blumberg H, Bhagwagar Z. Increased peripheral blood expression of electron transport chain genes in bipolar depression. Bipolar Disorders 2010, 12: 813-824. PMID: 21176028, PMCID: PMC3076072, DOI: 10.1111/j.1399-5618.2010.00882.x.Peer-Reviewed Original ResearchConceptsBipolar disorderBipolar depressionPeripheral bloodDepressed subjectsGeneGo MetaCore softwarePeripheral blood expressionHealthy control subjectsReal-time reverse transcription-polymerase chain reactionEffects of medicationReverse transcription-polymerase chain reactionQuantitative real-time reverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMitochondrial electron transport chainControl subjectsPolymerase chain reactionUnmedicated subjectsHealthy controlsBlood expressionBPD subjectsSpecific genetic pathwaysElectron transport chain genesMetaCore softwareA totalAltered expressionQRT-PCRLevetiracetam in the management of bipolar depression: a randomized, double-blind, placebo-controlled trial.
Saricicek A, Maloney K, Muralidharan A, Ruf B, Blumberg HP, Sanacora G, Lorberg B, Pittman B, Bhagwagar Z. Levetiracetam in the management of bipolar depression: a randomized, double-blind, placebo-controlled trial. The Journal Of Clinical Psychiatry 2010, 72: 744-50. PMID: 21034692, DOI: 10.4088/jcp.09m05659gre.Peer-Reviewed Original ResearchConceptsDepression Rating ScaleRating ScaleMean changeWeek 6Clinical Global Impression-Bipolar Version ScaleBipolar disorderHamilton Depression Rating Scale scoresMontgomery-Åsberg Depression Rating ScalePlacebo-controlled clinical trialDepression Rating Scale scoresHamilton Depression Rating ScaleYoung Mania Rating ScaleAdjunctive levetiracetam therapyLevetiracetam adjunctive therapySecondary efficacy assessmentsBipolar disorder type IPlacebo-controlled trialHamilton Anxiety Rating ScalePrimary efficacy measureSecondary outcome measuresMajor depressive episodeRating Scale scoresMania Rating ScaleShort-term treatmentSignificant differencesNeurotransmitter Systems in Bipolar Disorder
Nakic M, Krystal J, Bhagwagar Z. Neurotransmitter Systems in Bipolar Disorder. 2010, 210-227. DOI: 10.1002/9780470661277.ch16.Peer-Reviewed Original Research
2007
Bipolar disorder: the neglected psychosis
Bhagwagar Z, Goodwin G. Bipolar disorder: the neglected psychosis. Psychiatry 2007, 6: 389-392. DOI: 10.1016/j.mppsy.2007.06.005.Peer-Reviewed Original ResearchBipolar disorderAnti-manic actionMainstay of treatmentNon-pharmacological interventionsLong-term treatmentStage of illnessRole of intracellularBipolar depressionMonoaminergic transmissionDepressive episodeDrug treatmentEffective treatmentTherapeutic interventionsIllnessPatientsSignificant tollGold standardTreatmentEpisodesDisordersDepressionInterventionRelative lackAntipsychoticsPharmacotherapy
2005
Lamotrigine in the treatment of bipolar disorder
Bhagwagar Z, Goodwin G. Lamotrigine in the treatment of bipolar disorder. Expert Opinion On Pharmacotherapy 2005, 6: 1401-1408. PMID: 16013989, DOI: 10.1517/14656566.6.8.1401.Peer-Reviewed Original ResearchConceptsBipolar disorderIncidence of rashCommon side effectsLong-term treatmentTreatment of epilepsyCareful prescribingPivotal trialsNovel anticonvulsant agentGlutamatergic functionMood disordersSide effectsPsychiatric conditionsAnticonvulsant agentsMode of actionIon channel conductanceDisordersLamotrigineLong-term basisTreatmentEfficacyPlaceboRashPrescribingHeadachePatients
2004
Bipolar disorder: the neglected psychosis
Bhagwagar Z, Goodwin G. Bipolar disorder: the neglected psychosis. Psychiatry 2004, 3: 67-70. DOI: 10.1383/psyt.3.10.67.52406.Peer-Reviewed Original ResearchBipolar disorderMainstay of treatmentNon-pharmacological interventionsSerious chronic illnessTraditional mood stabilizersLong-term treatmentMonoaminergic neurotransmitter systemsYears of lifeAtypical antipsychoticsMood stabilizersLifetime riskChronic illnessNeurotransmitter systemsNovel anticonvulsantMedical disordersEarly interventionAccurate diagnosisIllnessDisordersCognitive-behavioral approachDiagnosisInterventionTreatmentAntipsychoticsValproate
2002
The role of lithium in the treatment of bipolar depression
Bhagwagar Z, Goodwin G. The role of lithium in the treatment of bipolar depression. Clinical Neuroscience Research 2002, 2: 222-227. DOI: 10.1016/s1566-2772(02)00046-4.Peer-Reviewed Original ResearchRole of mood stabilizers in bipolar disorder
Bhagwagar Z, Goodwin G. Role of mood stabilizers in bipolar disorder. Expert Review Of Neurotherapeutics 2002, 2: 239-248. PMID: 19811005, DOI: 10.1586/14737175.2.2.239.Peer-Reviewed Original Research