2021
Reflections on Anthony Zietman From Gastrointestinal Cancer and Physics Editors
Willett GCECG, Chang DT, Czito BG, Liauw SL, Wo JY, Klein PEE, Chen Z, Carlson DJ, Chetty IJ. Reflections on Anthony Zietman From Gastrointestinal Cancer and Physics Editors. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: 1114-1117. PMID: 34793734, DOI: 10.1016/j.ijrobp.2021.09.007.Peer-Reviewed Original Research
2019
High-dose-rate brachytherapy as monotherapy for prostate cancer: The impact of cellular repair and source decay
Tien CJ, Carlson DJ, Nath R, Chen ZJ. High-dose-rate brachytherapy as monotherapy for prostate cancer: The impact of cellular repair and source decay. Brachytherapy 2019, 18: 701-710. PMID: 31109870, DOI: 10.1016/j.brachy.2019.04.005.Peer-Reviewed Original ResearchAdaptive Imaging Versus Periodic Surveillance for Intrafraction Motion Management During Prostate Cancer Radiotherapy
Ma X, Yan H, Nath R, Chen Z, Li H, Liu W. Adaptive Imaging Versus Periodic Surveillance for Intrafraction Motion Management During Prostate Cancer Radiotherapy. Technology In Cancer Research & Treatment 2019, 18: 1533033819844489. PMID: 31177934, PMCID: PMC6558533, DOI: 10.1177/1533033819844489.Peer-Reviewed Original ResearchConceptsIntensity-modulated radiation therapyRadiation therapyCouch shiftsAutomatic motion compensationAdaptive imagingAutomatic correctionCurrent clinical situationProstate cancer radiotherapyImaging surveillanceMotion compensationPeriodic imaging surveillanceProstate cancerPeriodic surveillanceClinical situationsSurveillance strategiesBenefits of adaptivePeriodic imagingArc therapyMean percentageTherapyIntrafraction motion managementCancer radiotherapyRadiation therapy simulationTherapy simulationBeam delivery
2011
The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers
Chen Z, Roberts K, Decker R, Pathare P, Rockwell S, Nath R. The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers. Physics In Medicine And Biology 2011, 56: 4895-4912. PMID: 21772076, PMCID: PMC3154133, DOI: 10.1088/0031-9155/56/15/016.Peer-Reviewed Original ResearchMeSH KeywordsBrachytherapyCell SurvivalEdemaHumansMaleNeoplasm StagingProstateProstatic NeoplasmsRadioisotopesRadiotherapy DosageTreatment OutcomeConceptsPermanent interstitial brachytherapyProstate edemaProstate cancerEffects of edemaTumor control probabilityImpact of edemaInterstitial brachytherapyCell survivalEarly-stage prostate cancerControl probabilityStage prostate cancerCurrent clinical practiceProstate cancer cellsTumor cell proliferationInterstitial brachytherapy treatmentSublethal damage repairDose variationTumor cell survivalTumor characteristicsTumor controlClinical impactEdemaEdema evolutionClinical practiceProstate glandAn integrated approach to segmentation and nonrigid registration for application in image-guided pelvic radiotherapy
Lu C, Chelikani S, Papademetris X, Knisely JP, Milosevic MF, Chen Z, Jaffray DA, Staib LH, Duncan JS. An integrated approach to segmentation and nonrigid registration for application in image-guided pelvic radiotherapy. Medical Image Analysis 2011, 15: 772-785. PMID: 21646038, PMCID: PMC3164526, DOI: 10.1016/j.media.2011.05.010.Peer-Reviewed Original ResearchAlgorithmsBayes TheoremFemaleHumansImaging, Three-DimensionalMaleProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueSystems IntegrationTomography, X-Ray ComputedUterine Cervical NeoplasmsTesticular Doses in Image-Guided Radiotherapy of Prostate Cancer
Deng J, Chen Z, Yu JB, Roberts KB, Peschel RE, Nath R. Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2011, 82: e39-e47. PMID: 21489702, DOI: 10.1016/j.ijrobp.2011.01.071.Peer-Reviewed Original ResearchConceptsImage-guided radiotherapyTesticular dosesFull-fan modeProstate cancerFemoral headLess doseCBCT scansHalf-fan modeProstate cancer patientsKilovoltage cone-beamCancer patientsIntensity-modulated radiotherapy (IMRT) treatmentKilovoltage CBCTSuperior-inferior directionCone beamDosesCBCT fieldProstate patientsRectumDoseProstateMore doseRadiotherapy treatmentPatientsRadiotherapy
2010
Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia
Carlson DJ, Keall PJ, Loo BW, Chen ZJ, Brown JM. Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia. International Journal Of Radiation Oncology • Biology • Physics 2010, 79: 1188-1195. PMID: 21183291, PMCID: PMC3053128, DOI: 10.1016/j.ijrobp.2010.10.007.Peer-Reviewed Original ResearchConceptsTumor cell killingTumor hypoxiaCell killingRadiation fractionation schemesTumor biological effective doseBiological effective doseTumor cell killRegions of hypoxiaRadiotherapy regimenTreatment failureConventional fractionationNeck cancerStandard fractionationProstate cancerTumor cell populationFractionation schemeRadiation therapyTumor clonogensTumor oxygenationBlood vessels resultsCell killEffective doseAlternate fractionationResistant cellsHypoxiaResponse to “Comment on ‘AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137’” [Med. Phys. 36, 5310–5322 (2009)]
Nath R, Bice WS, Butler WM, Chen Z, Meigooni AS, Narayana V, Rivard MJ, Yu Y. Response to “Comment on ‘AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137’” [Med. Phys. 36, 5310–5322 (2009)]. Medical Physics 2010, 37: 1933-1933. PMID: 20443515, DOI: 10.1118/1.3358143.Peer-Reviewed Original ResearchIntegrated Segmentation and Nonrigid Registration for Application in Prostate Image-Guided Radiotherapy
Lu C, Chelikani S, Chen Z, Papademetris X, Staib LH, Duncan JS. Integrated Segmentation and Nonrigid Registration for Application in Prostate Image-Guided Radiotherapy. Lecture Notes In Computer Science 2010, 13: 53-60. PMID: 20879214, DOI: 10.1007/978-3-642-15705-9_7.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsHumansImaging, Three-DimensionalMaleProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueSystems IntegrationTomography, X-Ray ComputedConceptsManual segmentationAutomatic segmentationImportant treatment parametersNonrigid registrationImage-guided radiotherapy systemReal patient dataNon-rigid registrationIntegrated SegmentationRegistration partRadiotherapy linear acceleratorSegmentationTreatment imagesImage qualityCone-beam CTTreatment parametersImagesPromising resultsPatient dataKey anatomical structuresLinear acceleratorRegistrationPrevious workRadiotherapy system
2009
AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137
Nath R, Bice WS, Butler WM, Chen Z, Meigooni AS, Narayana V, Rivard MJ, Yu Y. AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137. Medical Physics 2009, 36: 5310-5322. PMID: 19994539, PMCID: PMC2776817, DOI: 10.1118/1.3246613.Peer-Reviewed Original ResearchConceptsBiological equivalent doseTumor volumeDose prescriptionStandard of careProstate cancer patientsPermanent interstitial brachytherapyAcute single dosesEffects of edemaCancer patientsSurgical traumaIntraoperative implantationSingle dosesClinical trialsProstate cancerRadiobiological modelsCurrent recommendationsInterstitial brachytherapyMore specific guidelinesRoutine patient treatmentsDifferent dose distributionsTreatment planPatient treatmentTarget volumeMost implantsDose distribution2D‐3D registration for prostate radiation therapy based on a statistical model of transmission images
Munbodh R, Tagare HD, Chen Z, Jaffray DA, Moseley DJ, Knisely JP, Duncan JS. 2D‐3D registration for prostate radiation therapy based on a statistical model of transmission images. Medical Physics 2009, 36: 4555-4568. PMID: 19928087, DOI: 10.1118/1.3213531.Peer-Reviewed Original ResearchAlgorithmsData Interpretation, StatisticalHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalInformation Storage and RetrievalMalePattern Recognition, AutomatedPhantoms, ImagingProstatic NeoplasmsRadiographic Image EnhancementRadiotherapy, ConformalReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueConstrained non-rigid registration for use in image-guided adaptive radiotherapy
Greene WH, Chelikani S, Purushothaman K, Knisely JP, Chen Z, Papademetris X, Staib LH, Duncan JS. Constrained non-rigid registration for use in image-guided adaptive radiotherapy. Medical Image Analysis 2009, 13: 809-817. PMID: 19682945, PMCID: PMC2771756, DOI: 10.1016/j.media.2009.07.004.Peer-Reviewed Original ResearchAlgorithmsArtificial IntelligenceHumansMalePattern Recognition, AutomatedProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedRadiotherapy, ConformalReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueTomography, X-Ray Computed
2008
Automated 2D–3D registration of portal images and CT data using line‐segment enhancement
Munbodh R, Chen Z, Jaffray DA, Moseley DJ, Knisely JP, Duncan JS. Automated 2D–3D registration of portal images and CT data using line‐segment enhancement. Medical Physics 2008, 35: 4352-4361. PMID: 18975681, PMCID: PMC3910153, DOI: 10.1118/1.2975143.Peer-Reviewed Original ResearchAlgorithmsArtificial IntelligenceHumansImaging, Three-DimensionalMalePattern Recognition, AutomatedProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueTomography, X-Ray ComputedA Constrained Non-rigid Registration Algorithm for Use in Prostate Image-Guided Radiotherapy
Greene W, Chelikani S, Purushothaman K, Chen Z, Knisely J, Staib L, Papademetris X, Duncan J. A Constrained Non-rigid Registration Algorithm for Use in Prostate Image-Guided Radiotherapy. Lecture Notes In Computer Science 2008, 11: 780-788. PMID: 18979817, PMCID: PMC2790815, DOI: 10.1007/978-3-540-85988-8_93.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsArtificial IntelligenceHumansImaging, Three-DimensionalMalePattern Recognition, AutomatedProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueTomography, X-Ray ComputedConceptsTreatment planProstate image-guided radiotherapyOriginal treatment planRadiation dosageImage-guided radiotherapyTreatment daysRadiotherapy treatment plansCritical organsDifferent patientsPatient dataDifferent treatment daysBladderRectumProstateFemurBone motionCT imagesDosageReal patient dataPatientsRadiotherapy
2007
On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy
Chen ZJ, Deng J, Roberts K, Nath R. On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy. International Journal Of Radiation Oncology • Biology • Physics 2007, 70: 303-310. PMID: 17980500, PMCID: PMC2289996, DOI: 10.1016/j.ijrobp.2007.09.007.Peer-Reviewed Original ResearchConceptsDose reductionProstate brachytherapyDose compensationLarge edemaBiochemical recurrence-free survivalRecurrence-free survivalSignificant dose reductionEffects of edemaSublethal damage repairAdditional irradiationPrescription doseProstate cancerIndividual patientsEdemaEdema evolutionPrescribed doseProstate edemaEffective doseRadiobiologic effectsBrachytherapyDoseProstate implantsDose responseImplants
2006
A gradient feature weighted Minimax algorithm for registration of multiple portal images to 3DCT volumes in prostate radiotherapy
Chelikani S, Purushothaman K, Knisely J, Chen Z, Nath R, Bansal R, Duncan J. A gradient feature weighted Minimax algorithm for registration of multiple portal images to 3DCT volumes in prostate radiotherapy. International Journal Of Radiation Oncology • Biology • Physics 2006, 65: 535-547. PMID: 16690436, PMCID: PMC2791048, DOI: 10.1016/j.ijrobp.2005.12.032.Peer-Reviewed Original ResearchAutomated 2D‐3D registration of a radiograph and a cone beam CT using line‐segment enhancementa)
Munbodh R, Jaffray DA, Moseley DJ, Chen Z, Knisely JP, Cathier P, Duncan JS. Automated 2D‐3D registration of a radiograph and a cone beam CT using line‐segment enhancementa). Medical Physics 2006, 33: 1398-1411. PMID: 16752576, PMCID: PMC2796183, DOI: 10.1118/1.2192621.Peer-Reviewed Original ResearchPotential impact of prostate edema on the dosimetry of permanent seed implants using the new (model CS‐1) seeds
Chen Z, Deng J, Roberts K, Nath R. Potential impact of prostate edema on the dosimetry of permanent seed implants using the new (model CS‐1) seeds. Medical Physics 2006, 33: 968-975. PMID: 16696473, DOI: 10.1118/1.2179170.Peer-Reviewed Original Research
2004
Iodine 125 Versus Palladium 103 Implants for Prostate Cancer
Peschel RE, Colberg JW, Chen Z, Nath R, Wilson LD. Iodine 125 Versus Palladium 103 Implants for Prostate Cancer. The Cancer Journal 2004, 10: 170-174. PMID: 15285926, DOI: 10.1097/00130404-200405000-00006.Peer-Reviewed Original ResearchConceptsExternal beam radiation therapyMinimum tumor doseDisease-free survival ratesComplication rateTumor doseProstate cancerRadiation therapyClinical outcomesPrognostic groupsBiochemical disease-free survival ratesSurvival rateBiochemical disease-free survivalDisease-free survivalHigh complication ratePoor prognostic groupProstate-specific antigenHormonal therapyT stageGleason scoreSingle institutionTransperineal implantationFavorable groupGrade 3Treatment groupsPatients
2003
Entropy-Based Dual-Portal-to-3-DCT Registration Incorporating Pixel Correlation
Bansal R, Staib LH, Chen Z, Rangarajan A, Knisely J, Nath R, Duncan JS. Entropy-Based Dual-Portal-to-3-DCT Registration Incorporating Pixel Correlation. IEEE Transactions On Medical Imaging 2003, 22: 29. PMID: 12703758, DOI: 10.1109/tmi.2002.806430.Peer-Reviewed Original ResearchConceptsRegistration frameworkImage dataMutual information-based registration algorithmRegistration parametersPortal imagesUltrasound image dataReal patient dataTomography image dataImage pixelsPixel correlationRegistration algorithmPatient setup verificationSegmentationPixel intensityMarkov random processInitial versionTransformation parametersAppropriate entropyImagesAlgorithmPatient dataFrameworkCT imagesLine processSetup verification