2011
The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers
Chen Z, Roberts K, Decker R, Pathare P, Rockwell S, Nath R. The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers. Physics In Medicine And Biology 2011, 56: 4895-4912. PMID: 21772076, PMCID: PMC3154133, DOI: 10.1088/0031-9155/56/15/016.Peer-Reviewed Original ResearchConceptsPermanent interstitial brachytherapyProstate edemaProstate cancerEffects of edemaTumor control probabilityImpact of edemaInterstitial brachytherapyCell survivalEarly-stage prostate cancerControl probabilityStage prostate cancerCurrent clinical practiceProstate cancer cellsTumor cell proliferationInterstitial brachytherapy treatmentSublethal damage repairDose variationTumor cell survivalTumor characteristicsTumor controlClinical impactEdemaEdema evolutionClinical practiceProstate gland
2005
Relative Biological Effectiveness of 103Pd and 125I Photons for Continuous Low-Dose-Rate Irradiation of Chinese Hamster Cells
Nath R, Bongiorni P, Chen Z, Gragnano J, Rockwell S. Relative Biological Effectiveness of 103Pd and 125I Photons for Continuous Low-Dose-Rate Irradiation of Chinese Hamster Cells. Radiation Research 2005, 163: 501-509. PMID: 15850411, DOI: 10.1667/rr3363.Peer-Reviewed Original ResearchConceptsContinuous low doseRate irradiationDose-rate effectInverse dose-rate effectCGy/hInitial dose rateChinese hamster lung cellsHigher initial dose rateLow doseHamster lung cellsLung cellsDose rateCell survivalX-ray beamRelative biological effectivenessChinese hamster cellsCellsImplantsAverage RBEHamster cellsBiological responsesBiological effectivenessMonoenergetic X-ray beam
2002
Edema-induced increase in tumour cell survival for 125I and 103Pd prostate permanent seed implants—a bio-mathematical model
Yue N, Chen Z, Nath R. Edema-induced increase in tumour cell survival for 125I and 103Pd prostate permanent seed implants—a bio-mathematical model. Physics In Medicine And Biology 2002, 47: 1185-1204. PMID: 11996063, DOI: 10.1088/0031-9155/47/7/313.Peer-Reviewed Original ResearchConceptsTumor potential doubling timeContinuous low dose rate irradiationTumor cell survivalSeed implantsBio-mathematical modelCell survivalExternal beam radiotherapyPresence of edemaProstate seed implantationLow dose rate irradiationEdema magnitudeEffects of edemaPotential doubling timeTypical edemaDose rate irradiationProstate volumeSurgical traumaPermanent seed implantsSeed implantationSignificant edemaTreatment strategiesSurgical proceduresBeam radiotherapyEdemaDose coverage