The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch
Hellman NE, Liu Y, Merkel E, Austin C, Le Corre S, Beier DR, Sun Z, Sharma N, Yoder BK, Drummond IA. The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 18499-18504. PMID: 20937855, PMCID: PMC2972951, DOI: 10.1073/pnas.1005998107.Peer-Reviewed Original ResearchConceptsCilia functionTektin-1Primary response geneRole of ciliaKidney cyst formationEpithelial stretchRenal cyst formationCiliogenic genesTranscriptional networksFoxj1a expressionDevelopmental patterningTranscriptional regulatorsTissue damageKidney ischemia-reperfusion injuryTranscription factorsFoxj1aOrgan homeostasisResponse genesCilia genesUncharacterized componentsCyst formationPronephric tubulesAcute kidney injuryIschemia-reperfusion injuryCilia motility