Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APCMin/+ Mice
Woo DK, Green PD, Santos JH, D'Souza AD, Walther Z, Martin WD, Christian BE, Chandel NS, Shadel GS. Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APCMin/+ Mice. American Journal Of Pathology 2011, 180: 24-31. PMID: 22056359, PMCID: PMC3338350, DOI: 10.1016/j.ajpath.2011.10.003.Peer-Reviewed Original ResearchConceptsMitochondrial genome instabilityGenome instabilityMtDNA instabilityMaintenance of mtDNAMitochondrial transcription factor AMitochondrial dysfunctionIntestinal tumorigenesisTranscription factor AWnt/β-catenin signalingMitochondrial oxidative phosphorylationMitochondrial ROS productionΒ-catenin signalingOxidative mtDNA damageReactive oxygen species productionMitochondrial DNAOxygen species productionMouse cellsOxidative phosphorylationOvert phenotypeMitochondrial ROSMtDNA damageMtDNA depletionCancer phenotypeAltered amountsTumorigenesis