2000
Attenuation of the Preoperative Stress Response with Midazolam
Kain Z, Sevarino F, Pincus S, Alexander G, Wang S, Ayoub C, Kosarussavadi B. Attenuation of the Preoperative Stress Response with Midazolam. Anesthesiology 2000, 93: 141-147. PMID: 10861157, DOI: 10.1097/00000542-200007000-00024.Peer-Reviewed Original ResearchConceptsPlacebo groupTreatment groupsPostoperative anxietyPreoperative sedativesPreoperative stress responsePlacebo-controlled trialFirst postoperative weekGreater reductionGlobal health indexAnalgesic consumptionIbuprofen usePlacebo injectionsPostoperative painClinical recoveryIntramuscular midazolamSurgery lengthPain recoveryPostoperative weekAnesthetic techniqueGeneral anesthesiaOutpatient surgeryPreoperative outcomesClinical significanceMidazolamSurgery
1999
Leptin and the Perioperative Neuroendocrinological Stress Response1
Kain Z, Zimolo Z, Heninger G. Leptin and the Perioperative Neuroendocrinological Stress Response1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 2438-2442. PMID: 10404818, DOI: 10.1210/jcem.84.7.5850.Peer-Reviewed Original ResearchConceptsSurgical stressLeptin decreaseHigh-dose opioid techniqueCortisol increasePhase IHigh-dose fentanylSurgical stress responseTotal abdominal hysterectomyCardiac surgery patientsBaseline 2 hPossible adverse outcomesBaseline 24 hPhase IIAcute stress responseDose fentanylAbdominal hysterectomyPostoperative morbiditySurgery patientsHysterectomy patientsLeptin levelsAnesthetic techniqueAdverse outcomesAdrenocortical axisCardiac patientsNeuroendocrine hormones