2021
Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure–Activity Relationships and Facilitates Mechanism of Action Studies
Wernke KM, Tirla A, Xue M, Surovtseva YV, Menges FS, Herzon SB. Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure–Activity Relationships and Facilitates Mechanism of Action Studies. Journal Of The American Chemical Society 2021, 143: 15824-15833. PMID: 34524796, DOI: 10.1021/jacs.1c07559.Peer-Reviewed Original ResearchConceptsFanconi anemia DNA repair pathwayBiosynthetic gene clusterDNA repair pathwaysGene clusterRepair pathwaysDNA bindingBacterial phenotypesInduces DNAGenotoxic effectsHuman microbiomeColibactinBiosynthetic precursorNatural product structuresBiological studiesPathwayStructure-activity relationshipsAction studiesGenotoxic metabolitesOrganismsOncogenesisDNATumorigenesisMicrobiomeFacilitate mechanismsPhenotype
2004
A C-terminal Myb Extension Domain Defines a Novel Family of Double-strand Telomeric DNA-binding Proteins in Arabidopsis *
Karamysheva Z, Surovtseva Y, Vespa L, Shakirov E, Shippen D. A C-terminal Myb Extension Domain Defines a Novel Family of Double-strand Telomeric DNA-binding Proteins in Arabidopsis *. Journal Of Biological Chemistry 2004, 279: 47799-47807. PMID: 15364931, DOI: 10.1074/jbc.m407938200.Peer-Reviewed Original ResearchConceptsPlant telomeric DNATelomeric DNA bindingDNA bindingTelomeric DNASingle Myb-like domainTelomeric DNA-binding proteinMyb-like domainDistinct gene familiesGenome data baseDNA-binding proteinsSearch of genesRegion C-terminalFamily 2Isolated C-terminal fragmentFamily 1Plant telomeresMyb domainArabidopsis genesGene familyC-terminal fragmentImmunoprecipitation experimentsC-terminusRecombinant proteinsC-terminalProtein composition