2019
The role of fatty acid binding protein 7 in spinal cord astrocytes in a mouse model of experimental autoimmune encephalomyelitis
Kamizato K, Sato S, Shil SK, Umaru BA, Kagawa Y, Yamamoto Y, Ogata M, Yasumoto Y, Okuyama Y, Ishii N, Owada Y, Miyazaki H. The role of fatty acid binding protein 7 in spinal cord astrocytes in a mouse model of experimental autoimmune encephalomyelitis. Neuroscience 2019, 409: 120-129. PMID: 31051217, DOI: 10.1016/j.neuroscience.2019.03.050.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisSpinal cordAutoimmune encephalomyelitisMultiple sclerosisWT miceMouse modelFabp7 KO miceSpinal cord astrocytesLumbar spinal cordInduction of inflammationWild-type miceCentral nervous systemProtein 7Role of FABP7Fatty acid homeostasisMRNA expression levelsLate phaseEAE onsetEAE symptomsAstrocyte activationClinical scoresFatty acidsInflammatory cytokinesMyelin degenerationType mice
2015
Fatty acid‐binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin‐1
Kagawa Y, Yasumoto Y, Sharifi K, Ebrahimi M, Islam A, Miyazaki H, Yamamoto Y, Sawada T, Kishi H, Kobayashi S, Maekawa M, Yoshikawa T, Takaki E, Nakai A, Kogo H, Fujimoto T, Owada Y. Fatty acid‐binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin‐1. Glia 2015, 63: 780-794. PMID: 25601031, DOI: 10.1002/glia.22784.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAstrocytesCaveolaeCaveolin 1Cell SurvivalCells, CulturedCerebral CortexCholesterolCytokinesFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGene Expression ProfilingGene Expression RegulationGlial Cell Line-Derived Neurotrophic FactorLipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsOligonucleotide Array Sequence AnalysisSignal TransductionTransduction, GeneticConceptsLipid raft functionCaveolin-1Raft functionLipid raftsFatty Acid Binding Protein 7Function of caveolaeReceptor-mediated signal transductionMitogen-activated protein kinaseRole of FABP7Toll-like receptor 4Caveolin-1 expressionExtracellular stimuliCavin-1Protein bindsSignal transductionCaveolin-2Flotillin-1Protein kinaseReceptor alpha 1Transcriptional levelLong-chain fatty acidsLipid dynamicsWild-type astrocytesLipid homeostasisTLR4 recruitment
2014
Fatty Acid Binding Protein 7 Regulates Phagocytosis and Cytokine Production in Kupffer Cells during Liver Injury
Miyazaki H, Sawada T, Kiyohira M, Yu Z, Nakamura K, Yasumoto Y, Kagawa Y, Ebrahimi M, Islam A, Sharifi K, Kawamura S, Kodama T, Yamamoto Y, Adachi Y, Tokuda N, Terai S, Sakaida I, Ishikawa T, Owada Y. Fatty Acid Binding Protein 7 Regulates Phagocytosis and Cytokine Production in Kupffer Cells during Liver Injury. American Journal Of Pathology 2014, 184: 2505-2515. PMID: 25041855, DOI: 10.1016/j.ajpath.2014.05.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCarbon TetrachlorideChemical and Drug Induced Liver InjuryCytokinesEnzyme-Linked Immunosorbent AssayFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsFlow CytometryFluorescent Antibody TechniqueImmunohistochemistryIn Situ Nick-End LabelingKupffer CellsMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsPhagocytosisReverse Transcriptase Polymerase Chain ReactionConceptsLiver injuryKupffer cellsKnockout miceLiver diseaseCytokine productionKC functionNumber of KCsKC phagocytic activityLiver injury processLiver necrotic areasChronic liver injurySerum liver enzymesWild-type miceNovel therapeutic approachesRole of FABP7Scavenger receptor CD36Cytokine expressionFibrogenic responseLiver enzymesInjury processPathological changesLiver cancerTherapeutic approachesReceptor CD36Tissue macrophages