2019
A single tyrosine phosphorylation site in cortactin is important for filopodia formation in neuronal growth cones
Ren Y, He Y, Brown S, Zbornik E, Mlodzianoski M, Ma D, Huang F, Mattoo S, Suter D. A single tyrosine phosphorylation site in cortactin is important for filopodia formation in neuronal growth cones. Molecular Biology Of The Cell 2019, 30: 1817-1833. PMID: 31116646, PMCID: PMC6727743, DOI: 10.1091/mbc.e18-04-0202.Peer-Reviewed Original ResearchConceptsTyrosine phosphorylation sitesPhosphorylation sitesFilopodia formationNeuronal growth conesSingle tyrosine phosphorylation sitePhosphorylated cortactinGrowth conesPhospho-mimetic mutantVitro kinase assaysFilopodia lengthFunction of cortactinTyrosine-phosphorylated cortactinFormation of filopodiaSrc tyrosine kinaseCortactin mutantMultiple actinPhosphorylation substratesActin organizationCellular processesLength of filopodiaKinase assaysCortactinTyrosine kinaseNonneuronal cellsFilopodia
2015
Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones
He Y, Ren Y, Wu B, Decourt B, Lee A, Taylor A, Suter D. Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones. Molecular Biology Of The Cell 2015, 26: 3229-3244. PMID: 26224308, PMCID: PMC4569314, DOI: 10.1091/mbc.e15-03-0142.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAplysiaAxonsCells, CulturedCortactinDown-RegulationGrowth ConesPseudopodiaSrc-Family KinasesUp-RegulationConceptsActin network densityGrowth conesSrc tyrosine kinaseFluorescent speckle microscopyState of actinNeuronal growth conesGrowth cone motilityLamellipodia protrusionActin organizationActin assemblyFilopodia formationActin bundlesAplysia growth conesSpeckle microscopyTyrosine kinaseUnderlying cellular mechanismsFilopodial densityCone motilityCellular mechanismsSrcFilopodiaActivation stateLamellipodiaSRC2Axonal growth