Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells
Fligor C, Langer K, Sridhar A, Ren Y, Shields P, Edler M, Ohlemacher S, Sluch V, Zack D, Zhang C, Suter D, Meyer J. Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells. Scientific Reports 2018, 8: 14520. PMID: 30266927, PMCID: PMC6162218, DOI: 10.1038/s41598-018-32871-8.Peer-Reviewed Original ResearchMeSH KeywordsCulture MediaGenes, ReporterHumansLuminescent ProteinsNeuronal OutgrowthOrganoidsPluripotent Stem CellsRetinal Ganglion CellsConceptsRetinal ganglion cellsRetinal organoidsAxonal outgrowthRGC developmentNeurite outgrowthExtensive axonal outgrowthRetinal ganglion cell developmentPost-synaptic targetsGanglion cell developmentStem cellsPluripotent stem cellsRGC layerThree-dimensional retinal organoidsGanglion cellsElaborate growth conesRGC differentiationHuman pluripotent stem cellsCellular replacementRetinal developmentGrowth factor signalingGrowth conesCell developmentOrganoidsFactor signalingGuidance receptors