2024
Cross-regulations of two connected domains form a mechanical circuit for steady force transmission during clathrin-mediated endocytosis
Ren Y, Yang J, Fujita B, Zhang Y, Berro J. Cross-regulations of two connected domains form a mechanical circuit for steady force transmission during clathrin-mediated endocytosis. Cell Reports 2024, 43: 114725. PMID: 39276354, PMCID: PMC11476202, DOI: 10.1016/j.celrep.2024.114725.Peer-Reviewed Original ResearchClathrin-mediated endocytosisF-actinActin cytoskeletonFission yeast Schizosaccharomyces pombeYeast Schizosaccharomyces pombeCell adhesion complexAdhesion complexesMembrane localizationPN forcesStable bindingEnd4pCross-regulationCytoskeletonActinEndocytosisMembraneBindingMechanical forcesTalinTransmission of forcesThatchForce transmissionDomainCellsFission
2021
Rapid adaptation of endocytosis, exocytosis and eisosomes after an acute increase in membrane tension in yeast cells
Lemière J, Ren Y, Berro J. Rapid adaptation of endocytosis, exocytosis and eisosomes after an acute increase in membrane tension in yeast cells. ELife 2021, 10: e62084. PMID: 33983119, PMCID: PMC9045820, DOI: 10.7554/elife.62084.Peer-Reviewed Original ResearchConceptsClathrin-mediated endocytosisMembrane tensionActin machineryYeast cellsFission yeast cellsRate of endocytosisRate of exocytosisActin assemblyLarge membrane tensionPlasma membraneCell wallMolecular mechanismsTurgor pressureEndocytosisRapid adaptationEisosomesExocytosisMachineryQuantitative microscopyMinute time scaleHypotonic shockCellsEukaryotesMembraneTension regulation
2012
Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cells
Zhang C, Sun X, Ren Y, Lou Y, Zhou J, Liu M, Li D. Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cells. Cancer Biology & Therapy 2012, 13: 1214-1220. PMID: 22892842, PMCID: PMC3469479, DOI: 10.4161/cbt.21412.Peer-Reviewed Original ResearchConceptsPancreatic cancer cellsCancer cellsPolo-like kinase 1Human pancreatic cancer cellsChemotherapeutic drug gemcitabinePLK1 inhibitorsCombination index analysisKinase 1Pancreatic cancerClinical investigationTherapeutic targetCancer treatmentExpression levelsDrug gemcitabineValuable targetCellsTreatmentInhibitorsProliferationCritical roleCep70 promotes microtubule assembly in vitro by increasing microtubule elongation
Shi X, Wang J, Yang Y, Ren Y, Zhou J, Li D. Cep70 promotes microtubule assembly in vitro by increasing microtubule elongation. Acta Biochimica Et Biophysica Sinica 2012, 44: 450-454. PMID: 22427462, DOI: 10.1093/abbs/gms017.Peer-Reviewed Original ResearchConceptsCentrosomal proteinsMicrotubule assemblyMajor microtubule-organizing centerNovel centrosomal proteinDynamic cytoskeletal polymersMicrotubule-organizing centerMicrotubule elongationEukaryotic cellsMammalian cellsAnimal cellsMolecular detailsCep70Microtubule nucleationMolecular mechanismsCytoskeletal polymersMicrotubule lengthProteinMicrotubule numberAssemblyCellsCentrosomesElongationMicrotubulesInhibition of farnesyltransferase reduces angiogenesis by interrupting endothelial cell migration
Peng G, Ren Y, Sun X, Zhou J, Li D. Inhibition of farnesyltransferase reduces angiogenesis by interrupting endothelial cell migration. Biochemical Pharmacology 2012, 83: 1374-1382. PMID: 22382068, DOI: 10.1016/j.bcp.2012.02.008.Peer-Reviewed Original ResearchConceptsEndothelial cellsCell migrationInhibition of farnesyltransferaseTherapeutic targetTumor cellsCancer treatmentEndothelial cell migrationUse of FTIsProtein 1Cancer therapyAngiogenesisPseudopodia formationInhibition of FTaseInhibitors of farnesyltransferaseInhibitionCellsLocalization of EB1Novel insightsPhysiological processesTherapy