Spontaneous Fusion with Transformed Mesenchymal Stromal Cells Results in Complete Heterogeneity in Prostate Cancer Cells
Wang R, Hu P, Wang F, Lyu J, Ou Y, Edderkaoui M, Zhang Y, Lewis M, Pandol S, Zhau H, Chung L. Spontaneous Fusion with Transformed Mesenchymal Stromal Cells Results in Complete Heterogeneity in Prostate Cancer Cells. Cancers 2024, 16: 951. PMID: 38473313, PMCID: PMC10931070, DOI: 10.3390/cancers16050951.Peer-Reviewed Original ResearchProstate cancer cellsStromal cell lineBystander cellsCancer cellsCell linesTumor cell heterogeneityFusion hybridsMesenchymal stromal cellsCell fusionTumor microenvironmentGenomic hybridizationTumor cellsMesenchymal stromal cell lineStromal cellsTumorDerivative clonesPhenotypic heterogeneityCell compartmentPhenotypic diversificationGenomic makeupBehavioral phenotypesCell heterogeneitySpontaneous fusionDerivative subclonesSublines