Overcoming Resistance in Prostate Cancer Therapy Using a DZ-Simvastatin Conjugate
Ou Y, Chu G, Lyu J, Yin L, Lim A, Zhai N, Cui X, Lewis M, Edderkaoui M, Pandol S, Wang R, Zhang Y. Overcoming Resistance in Prostate Cancer Therapy Using a DZ-Simvastatin Conjugate. Molecular Pharmaceutics 2024, 21: 873-882. PMID: 38229228, PMCID: PMC11025579, DOI: 10.1021/acs.molpharmaceut.3c00993.Peer-Reviewed Original ResearchConceptsProstate cancerTherapeutic resistanceTarget PC cellsAndrogen receptor statusTraditional systemic treatmentsSuppressed xenograft tumor formationProstate cancer therapyCastration-resistant formTumor cell targetsPC cellsSignificant side effectsCancer-related deathsCell deathHeptamethine carbocyanine dyeXenograft tumor formationPC cell linesXenograft tumor modelReceptor statusHormone therapySystemic treatmentSafety profileTumor cellsChemotherapeutic drugsTumor modelCancer therapy