2014
Computational Analysis in Cancer Exome Sequencing
Evans P, Kong Y, Krauthammer M. Computational Analysis in Cancer Exome Sequencing. Methods In Molecular Biology 2014, 1176: 219-227. PMID: 25030931, DOI: 10.1007/978-1-4939-0992-6_18.Peer-Reviewed Original ResearchMeSH KeywordsComputational BiologyDNA Copy Number VariationsExomeHigh-Throughput Nucleotide SequencingHumansINDEL MutationLoss of HeterozygosityMutationNeoplasmsPolymorphism, Single NucleotideConceptsSomatic single nucleotide variantsMutational eventsSingle nucleotide variantsHuman genesSequencing readsShort insertionsDriver genesNucleotide variantsNumber alterationsExome sequencingGenesCancer samplesComputational analysisMore mutational eventsPowerful toolComputational methodsExomeSequencingDeletionReads
2012
Exon capture and bulk segregant analysis: rapid discovery of causative mutations using high-throughput sequencing
del Viso F, Bhattacharya D, Kong Y, Gilchrist MJ, Khokha MK. Exon capture and bulk segregant analysis: rapid discovery of causative mutations using high-throughput sequencing. BMC Genomics 2012, 13: 649. PMID: 23171430, PMCID: PMC3526394, DOI: 10.1186/1471-2164-13-649.Peer-Reviewed Original ResearchConceptsBulk segregant analysisForward genetic screenSegregant analysisGenetic screenGenome assemblyExon captureCausative mutationsVertebrate model systemHigh-throughput sequencingHuman genetic analysisThousands of SNPsAssembly of scaffoldsModel systemGenomic resourcesVertebrate modelXenopus tropicalisFine mappingGenetic analysisCapture sequencingSequence variantsSequencingMutationsRapid discoveryMutantsExome sequencingLength distribution of sequencing by synthesis: fixed flow cycle model
Kong Y. Length distribution of sequencing by synthesis: fixed flow cycle model. Journal Of Mathematical Biology 2012, 67: 389-410. PMID: 22689207, DOI: 10.1007/s00285-012-0556-3.Peer-Reviewed Original Research
2011
Btrim: A fast, lightweight adapter and quality trimming program for next-generation sequencing technologies
Kong Y. Btrim: A fast, lightweight adapter and quality trimming program for next-generation sequencing technologies. Genomics 2011, 98: 152-153. PMID: 21651976, DOI: 10.1016/j.ygeno.2011.05.009.Peer-Reviewed Original Research