2024
De Novo Elastin Assembly Alleviates Development of Supravalvular Aortic Stenosis—Brief Report
Ellis M, Riaz M, Huang Y, Anderson C, Hoareau M, Li X, Luo H, Lee S, Park J, Luo J, Batty L, Huang Q, Lopez C, Reinhardt D, Tellides G, Qyang Y. De Novo Elastin Assembly Alleviates Development of Supravalvular Aortic Stenosis—Brief Report. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 1674-1682. PMID: 38752350, PMCID: PMC11209776, DOI: 10.1161/atvbaha.124.320790.Peer-Reviewed Original ResearchSupravalvular aortic stenosisVascular smooth muscle cellsSmooth muscle cellsMuscle cellsAortic stenosisMedial vascular smooth muscle cellsVascular proliferative diseasesEpigallocatechin gallate treatmentProliferative abnormalitiesPreclinical findingsHeart failureLuminal occlusionMouse modelCell hyperproliferationDefective elastinProliferative diseasesCardiovascular disordersFormation of elastinTherapeutic interventionsElastin assemblyElastin depositionStenosisMiceAortic mechanicsImproper formation
2018
Modeling elastin-associated vasculopathy with patient induced pluripotent stem cells and tissue engineering
Ellis MW, Luo J, Qyang Y. Modeling elastin-associated vasculopathy with patient induced pluripotent stem cells and tissue engineering. Cellular And Molecular Life Sciences 2018, 76: 893-901. PMID: 30460472, PMCID: PMC6433159, DOI: 10.1007/s00018-018-2969-7.Peer-Reviewed Original ResearchConceptsExtracellular matrix protein elastinAberrant vascular smooth muscle cell (VSMC) proliferationPatient induced pluripotent stem cellsInduced pluripotent stem cellsHuman disease modelingPluripotent stem cell (iPSC) technologyPluripotent stem cellsDrug screening approachesVascular proliferative diseasesVascular smooth muscle cell proliferationStem cell technologyProtein elastinReplenishable supplyDisruption of functionSmooth muscle cell proliferationDisease modelingStem cellsMuscle cell proliferationCell proliferationScreening approachTherapeutic developmentProliferative diseasesElastinBlood vessel dysfunctionTissue engineering