Downregulation of Sirt6 by CD38 promotes cell senescence and aging
Zhou H, Liu S, Zhang N, Fang K, Zong J, An Y, Chang X. Downregulation of Sirt6 by CD38 promotes cell senescence and aging. Aging 2022, 14: 9730-9757. PMID: 36490326, PMCID: PMC9792202, DOI: 10.18632/aging.204425.Peer-Reviewed Original ResearchMeSH KeywordsADP-ribosyl Cyclase 1AgingAnimalsCell LineCellular SenescenceDown-RegulationMembrane GlycoproteinsMiceNADRatsRNA, Small InterferingSirtuinsConceptsCD38 expressionSIRT6 expressionC3GCD38 siRNACell senescenceIncreased SIRT6 expressionMechanism of CD38H9c2 cellsInduced to senescenceTelomerase reverse transcriptase levelsReverse transcriptase levelsNK cell levelsPresence of C3GNicotinamide adenine dinucleotidePromote cell senescenceReduced reactive oxygen speciesTNF-a levelsDecreased SIRT6 expressionReactive oxygen speciesD-gal induced senescenceHexokinase 2OSS-128167Myocardial H9c2 cellsStimulate cell proliferationSiRNA