2024
Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells
Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong S, Link T, Gallup T, Qie Y, Li X, Dong S, Schrank B, Grippin A, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong A, Tainer J, Jiang W, Kim B. Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells. Nature Biomedical Engineering 2024, 8: 593-610. PMID: 38641710, PMCID: PMC11162332, DOI: 10.1038/s41551-024-01194-7.Peer-Reviewed Original ResearchAntigen-presenting cellsInnate immune pathwaysImmune pathwaysPriming of effector T cellsImmune checkpoint inhibitorsAntitumour immune responseEffector T cellsIntracellular DNA-sensing pathwaysMetastatic breast cancerSyngeneic mouse modelMultiple innate immune pathwaysAdaptive immunogenicityAntitumour responseCheckpoint inhibitorsEndoplasmic reticulum stressT cellsSystemic clearanceBreast cancerDNA-sensing pathwayRelease of mitochondrial DNATherapeutic advantageMouse modelImmune responseEfficient primingIntracellular delivery
2021
Strong association of glaucoma with atherosclerosis
Song X, Li P, Li Y, Yan X, Yuan L, Zhao C, An Y, Chang X. Strong association of glaucoma with atherosclerosis. Scientific Reports 2021, 11: 8792. PMID: 33888852, PMCID: PMC8062555, DOI: 10.1038/s41598-021-88322-4.Peer-Reviewed Original ResearchConceptsAqueous humor secretionPrimary diagnosisHumor secretionAS prevalencePrimary diagnosis of glaucomaPrimary diagnosis of hypertensionAngle-closure glaucomaHigh intraocular pressureAssociation of glaucomaDiagnosis of glaucomaEffects of methazolamideLow-density lipoprotein (LDLDiagnosis of hypertensionReduce low-density lipoprotein (LDLGlaucoma prevalenceIntraocular pressureLipoprotein (LDLGlaucoma pathogenesisOphthalmic recordsTreat glaucomaAS patientsGlaucomaOphthalmic diseasesMouse modelIncidence of A