Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Roberts W, Verplaetse T, Burke C, Morris E, McKee S, Cosgrove K. Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes. Nicotine & Tobacco Research 2022, 25: 1047-1051. PMID: 36107715, PMCID: PMC10077933, DOI: 10.1093/ntr/ntac215.Peer-Reviewed Original ResearchMeSH KeywordsAmphetamineCigarette SmokingDopamineFemaleHumansMalePositron-Emission TomographyPrefrontal CortexVerbal LearningConceptsCognitive functionVerbal learningPrefrontal cortexCognitive deficitsWorse verbal learningBrain-behavior relationshipsD2R availabilityDorsolateral prefrontal cortexCognitive performanceComputerized testsTask performanceCogState batteryInhibitory controlNeurocognitive testsReceptor availabilityMesocortical dopaminePositron emission tomographyDopamine D2/3 receptor availabilityMemoryCognitionD2/3 receptor availabilityDopamine releaseSmoking variablesSubject samplesDeficitsSystemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers
Zakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers. Brain Behavior And Immunity 2022, 106: 262-269. PMID: 36058419, PMCID: PMC10097458, DOI: 10.1016/j.bbi.2022.08.016.Peer-Reviewed Original ResearchMeSH KeywordsCentral Nervous System StimulantsCorpus StriatumDopamineHumansInflammationLipopolysaccharidesMethylphenidatePositron-Emission TomographyRacloprideSmokersConceptsEffects of LPSDopamine elevationTobacco smokersHealthy controlsSystemic inflammationDopamine systemImmune-brain interactionReward-related brain regionsAdministration of placeboAdministration of LPSSmoking statusRepeated-measures ANOVAPathophysiology of addictionDrug dosingPlaceboIndependent cohortSmokersDrug reinforcementEffect size determinationImmune systemRandomized orderBrain regionsLPSMethylphenidatePBO conditionDesigning Neuroimaging Studies to Help Inform the Clinical Treatment of Addiction
Zakiniaeiz Y, Cosgrove KP. Designing Neuroimaging Studies to Help Inform the Clinical Treatment of Addiction. Biological Psychiatry 2020, 88: 741-743. PMID: 33092691, PMCID: PMC11265605, DOI: 10.1016/j.biopsych.2020.08.011.Peer-Reviewed Original ResearchAmphetamineCarbon RadioisotopesCocaine-Related DisordersDopamineHumansNeuroimagingPositron-Emission TomographyPyrrolidinesSalicylamidesToward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex
Liu H, Zakiniaeiz Y, Cosgrove KP, Morris ED. Toward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex. Brain Imaging And Behavior 2017, 13: 314-322. PMID: 29071465, PMCID: PMC5918462, DOI: 10.1007/s11682-017-9779-7.Peer-Reviewed Original ResearchMeSH KeywordsBenzamidesCerebral CortexCorpus StriatumDopamineHumansPositron-Emission TomographyRacloprideRadiopharmaceuticalsSex FactorsSmokingConceptsDA releaseDA receptorsDA changesCortical DA releaseMesocorticolimbic dopamine circuitRecent PET studiesPositron emission tomography (PET) radiotracerMesocortical DA pathwaysMesocortical systemCigarette smokingDA pathwayDA transmissionMesolimbic pathwayDopamine transmissionMesocortical DAWhole brainDopamine circuitsNovel high affinityTomography radiotracerPET studiesPET dataStriatumPET imagingEffects of stressCortexSex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers
Zakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers. Neuropsychopharmacology 2019, 44: 2205-2211. PMID: 31269510, PMCID: PMC6897943, DOI: 10.1038/s41386-019-0456-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdultAmphetamineDopamineFemaleHumansMalePositron-Emission TomographyPrefrontal CortexReceptors, Dopamine D2Sex CharacteristicsSmokersConceptsDA releasePositron emission tomographyD2R availabilityDorsolateral prefrontal cortexMale smokersFemale smokersTobacco smokingPrefrontal cortexAmphetamine-induced DA releaseAmphetamine-induced dopamine releaseCortical DA releaseMesocortical DA systemEffects of nicotineSmoking-related behaviorsMesolimbic dopamine systemLong-term abstinenceSex differencesGender-specific treatmentFemale nonsmokersTobacco smokersAmphetamine administrationDopamine releaseNeurochemical mechanismsNonsmokersSmokers