Toward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex
Liu H, Zakiniaeiz Y, Cosgrove KP, Morris ED. Toward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex. Brain Imaging And Behavior 2017, 13: 314-322. PMID: 29071465, PMCID: PMC5918462, DOI: 10.1007/s11682-017-9779-7.Peer-Reviewed Original ResearchConceptsDA releaseDA receptorsDA changesCortical DA releaseMesocorticolimbic dopamine circuitRecent PET studiesPositron emission tomography (PET) radiotracerMesocortical DA pathwaysMesocortical systemCigarette smokingDA pathwayDA transmissionMesolimbic pathwayDopamine transmissionMesocortical DAWhole brainDopamine circuitsNovel high affinityTomography radiotracerPET studiesPET dataStriatumPET imagingEffects of stressCortexLower Dorsal Putamen D2/3 Receptor Availability and Amphetamine-Induced Dopamine Release are Related to Poorer Cognitive Function in Recently Abstinent People Who Smoke and Healthy Controls
Cheung F, Calakos K, Gueorguieva R, Hillmer A, Cosgrove K, Zakiniaeiz Y. Lower Dorsal Putamen D2/3 Receptor Availability and Amphetamine-Induced Dopamine Release are Related to Poorer Cognitive Function in Recently Abstinent People Who Smoke and Healthy Controls. Nicotine & Tobacco Research 2024, 26: 1038-1044. PMID: 38367211, PMCID: PMC11260895, DOI: 10.1093/ntr/ntae031.Peer-Reviewed Original ResearchAmphetamine-induced dopamine releaseBrain-behavior relationshipsAbstinent peopleDorsal striatumCognitive functionDopamine releasePoorer cognitive functionD2/3R availabilityDelayed recallHealthy controlsTests of verbal learningDysregulated dopamine signalingD2/3 receptor availabilityDrug-seeking behaviorDorsolateral prefrontal cortexCogState computerized batteryPositron emission tomography scanAmphetamine administrationMesocortical pathwayMesolimbic pathwayDopamine systemPrefrontal cortexVerbal learningBaseline BPNDDopamine signaling