Featured Publications
Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice
Yang X, Wang Z, Niu J, Zhai R, Xue X, Wu G, Fang Y, Meng G, Yuan H, Zhao L, Zhang C. Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice. Microbiome 2023, 11: 62. PMID: 36978130, PMCID: PMC10052834, DOI: 10.1186/s40168-023-01507-z.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetesBeta-cell destructionGut microbiotaGut microbiomeDextran sulfate sodium treatmentAutoimmune type 1 diabetesCell destructionIDD developmentDysbiotic gut microbiotaGerm-free micePotential human relevanceType 1 diabetesNormal gut microbiomeGut pathobiontPancreatic inflammationC57BL/6 miceLocal inflammationNormal dietWildtype miceAnimal modelsDiabetesSodium treatmentPathobiontsPancreasHuman relevance
2023
Microbiota-derived acetate enhances host antiviral response via NLRP3
Niu J, Cui M, Yang X, Li J, Yao Y, Guo Q, Lu A, Qi X, Zhou D, Zhang C, Zhao L, Meng G. Microbiota-derived acetate enhances host antiviral response via NLRP3. Nature Communications 2023, 14: 642. PMID: 36746963, PMCID: PMC9901394, DOI: 10.1038/s41467-023-36323-4.Peer-Reviewed Original ResearchConceptsViral infectionGut-lung axisRespiratory viral infectionsNLRP3-deficient miceIFN-I productionHost immune responsePathogenic viral infectionPotential therapeutic targetType I interferonHost antiviral responseRespiratory virusesIAV infectionMAVS aggregationNLRP3 inflammasomeDeficient miceImmune responseProtective effectTherapeutic targetI interferonGut microbiotaAntiviral responseNLRP3Host defenseInfectionEnhanced induction
2022
A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease
Cheng R, Wang L, Le S, Yang Y, Zhao C, Zhang X, Yang X, Xu T, Xu L, Wiklund P, Ge J, Lu D, Zhang C, Chen L, Cheng S. A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease. Nature Communications 2022, 13: 2555. PMID: 35538056, PMCID: PMC9091228, DOI: 10.1038/s41467-022-29968-0.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseDiet interventionPrimary outcomeLiver diseaseTreatment of NAFLDThird primary outcomeTRIAL REGISTRATION NUMBERLiver fat contentCombined aerobic exerciseEffects of interventionsLiver fatAerobic exerciseGlucose metabolismGut microbiotaRegistration numberLarger sample sizeMicrobiota compositionExploratory adPatientsAdverse effectsInterventionIntervention strategiesPrediabetesExerciseChronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice
Zhang Y, Luo H, Niu Y, Yang X, Li Z, Wang K, Bi H, Pang X. Chronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice. Sleep Medicine 2022, 91: 84-92. PMID: 35286865, DOI: 10.1016/j.sleep.2022.02.003.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCo-abundance groupsChronic intermittent hypoxiaIntermittent hypoxiaSystemic inflammationGut microbiotaGut microbiomeElevated systemic inflammationAdverse metabolic outcomesGut microbial dysbiosisMale C57BL/6 micePrevalent sleep disorderFatty acid metabolismIH miceIH exposureMetabolic riskSleep apneaC57BL/6 miceMicrobial dysbiosisComposition of microbiotaMetabolic outcomesIntestinal microbial communityMetabolism disordersMetabolic dysfunctionSleep disorders
2021
Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites
Li Y, Yang X, Zhang J, Jiang T, Zhang Z, Wang Z, Gong M, Zhao L, Zhang C. Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites. MBio 2021, 12: 10.1128/mbio.03601-20. PMID: 33785628, PMCID: PMC8092315, DOI: 10.1128/mbio.03601-20.Peer-Reviewed Original ResearchConceptsKetogenic dietGut microbiotaProportion of fatLipid metabolismGlucose intoleranceInsulin resistanceFat accumulationMouse trialsNeurodegenerative diseasesLipid accumulationMore fat accumulationInduced glucose intoleranceLipid metabolism disordersAffected lipid metabolismMetabolism disordersMetabolic disordersGlucose homeostasisGlucose metabolismSource of fatHuman studiesHigh fatTreatment of diseasesMiceBeneficial effectsWeight loss
2020
Gut Bacteria Shared by Children and Their Mothers Associate with Developmental Level and Social Deficits in Autism Spectrum Disorder
Chen Y, Fang H, Li C, Wu G, Xu T, Yang X, Zhao L, Ke X, Zhang C. Gut Bacteria Shared by Children and Their Mothers Associate with Developmental Level and Social Deficits in Autism Spectrum Disorder. MSphere 2020, 5: 10.1128/msphere.01044-20. PMID: 33268567, PMCID: PMC7716279, DOI: 10.1128/msphere.01044-20.Peer-Reviewed Original Research
2019
Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice
Zhai R, Xue X, Zhang L, Yang X, Zhao L, Zhang C. Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice. Frontiers In Cellular And Infection Microbiology 2019, 9: 239. PMID: 31334133, PMCID: PMC6624636, DOI: 10.3389/fcimb.2019.00239.Peer-Reviewed Original ResearchMeSH KeywordsAkkermansiaAnimalsAnti-Inflammatory AgentsCD4-Positive T-LymphocytesChronic DiseaseColitisColonCytokinesDextran SulfateDisease Models, AnimalDysbiosisFecesGastrointestinal MicrobiomeHT29 CellsHumansInterferon-gammaInterleukin-8MaleMiceMice, Inbred C57BLProbioticsRNA, Ribosomal, 16STumor Necrosis Factor-alphaVerrucomicrobiaWhole Genome SequencingConceptsInflammatory bowel diseaseAnti-inflammatory propertiesAnti-inflammatory effectsChronic colitisInflammation indexSpleen weightGut microbiotaBeneficial effectsSimilar anti-inflammatory propertiesColon histological scoresDifferentiation of TregsDextran sulfate sodiumPro-inflammatory cytokinesT cell populationsIL-8 productionColon of micePotential beneficial effectsShort-chain fatty acidsBowel diseaseIntestinal dysbiosisSulfate sodiumClinical parametersHT-29 cellsHistological scoresStrain-specific characteristics