2023
Microbiota-derived acetate enhances host antiviral response via NLRP3
Niu J, Cui M, Yang X, Li J, Yao Y, Guo Q, Lu A, Qi X, Zhou D, Zhang C, Zhao L, Meng G. Microbiota-derived acetate enhances host antiviral response via NLRP3. Nature Communications 2023, 14: 642. PMID: 36746963, PMCID: PMC9901394, DOI: 10.1038/s41467-023-36323-4.Peer-Reviewed Original ResearchConceptsViral infectionGut-lung axisRespiratory viral infectionsNLRP3-deficient miceIFN-I productionHost immune responsePathogenic viral infectionPotential therapeutic targetType I interferonHost antiviral responseRespiratory virusesIAV infectionMAVS aggregationNLRP3 inflammasomeDeficient miceImmune responseProtective effectTherapeutic targetI interferonGut microbiotaAntiviral responseNLRP3Host defenseInfectionEnhanced induction
2022
A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease
Cheng R, Wang L, Le S, Yang Y, Zhao C, Zhang X, Yang X, Xu T, Xu L, Wiklund P, Ge J, Lu D, Zhang C, Chen L, Cheng S. A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease. Nature Communications 2022, 13: 2555. PMID: 35538056, PMCID: PMC9091228, DOI: 10.1038/s41467-022-29968-0.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseDiet interventionPrimary outcomeLiver diseaseTreatment of NAFLDThird primary outcomeTRIAL REGISTRATION NUMBERLiver fat contentCombined aerobic exerciseEffects of interventionsLiver fatAerobic exerciseGlucose metabolismGut microbiotaRegistration numberLarger sample sizeMicrobiota compositionExploratory adPatientsAdverse effectsInterventionIntervention strategiesPrediabetesExercise