Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice
Zhai R, Xue X, Zhang L, Yang X, Zhao L, Zhang C. Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice. Frontiers In Cellular And Infection Microbiology 2019, 9: 239. PMID: 31334133, PMCID: PMC6624636, DOI: 10.3389/fcimb.2019.00239.Peer-Reviewed Original ResearchMeSH KeywordsAkkermansiaAnimalsAnti-Inflammatory AgentsCD4-Positive T-LymphocytesChronic DiseaseColitisColonCytokinesDextran SulfateDisease Models, AnimalDysbiosisFecesGastrointestinal MicrobiomeHT29 CellsHumansInterferon-gammaInterleukin-8MaleMiceMice, Inbred C57BLProbioticsRNA, Ribosomal, 16STumor Necrosis Factor-alphaVerrucomicrobiaWhole Genome SequencingConceptsInflammatory bowel diseaseAnti-inflammatory propertiesAnti-inflammatory effectsChronic colitisInflammation indexSpleen weightGut microbiotaBeneficial effectsSimilar anti-inflammatory propertiesColon histological scoresDifferentiation of TregsDextran sulfate sodiumPro-inflammatory cytokinesT cell populationsIL-8 productionColon of micePotential beneficial effectsShort-chain fatty acidsBowel diseaseIntestinal dysbiosisSulfate sodiumClinical parametersHT-29 cellsHistological scoresStrain-specific characteristics