Featured Publications
Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Wang P, Yang X, Zhang L, Sha S, Huang J, Peng J, Gu J, Pearson J, Hu Y, Zhao H, Wong F, Wang Q, Wen L. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 2024, 15: 4232. PMID: 38762479, PMCID: PMC11102548, DOI: 10.1038/s41467-024-48611-8.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Gut microbiotaGut microbial communityTransferred to germ-free miceB cellsGerm-free miceTLR9 deficiencyKO miceGene sequencesGerminal center B cellsMicrobial communitiesMarginal zone B cellsGut dysbiosisFollicular helper cellsSelf-DNAMetabolic homeostasisAssociated with increased frequencyPro-inflammatory stateFat tissue inflammationGutHigh-fat dietMicrobiotaHelper cellsT cellsControl mice
2024
The profile of blood microbiome in new-onset type 1 diabetes children
Yuan X, Yang X, Xu Z, Li J, Sun C, Chen R, Wei H, Chen L, Du H, Li G, Yang Y, Chen X, Cui L, Fu J, Wu J, Chen Z, Fang X, Su Z, Zhang M, Wu J, Chen X, Zhou J, Luo Y, Zhang L, Wang R, Luo F. The profile of blood microbiome in new-onset type 1 diabetes children. IScience 2024, 27: 110252. PMID: 39027370, PMCID: PMC11255850, DOI: 10.1016/j.isci.2024.110252.Peer-Reviewed Original ResearchBlood microbiomeRRNA gene sequencesMicrobiome of patientsGene sequencesOral microbiomePICRUSt analysisMicrobial featuresMicrobiome signaturesPathogenic bacteriaMicrobiomeTranslocation of bacteriaPotential translocationBacteriaRandom forest analysisType 1 diabetic childrenGutNew-onset T1DDiscriminatory powerType 1 diabetesForest analysisOral cavityIncreasing diversityInduce inflammationPICRUStGenus