2008
Urocortin2 inhibits tumor growth via effects on vascularization and cell proliferation
Hao Z, Huang Y, Cleman J, Jovin IS, Vale WW, Bale TL, Giordano FJ. Urocortin2 inhibits tumor growth via effects on vascularization and cell proliferation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 3939-3944. PMID: 18308934, PMCID: PMC2268793, DOI: 10.1073/pnas.0712366105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, Lewis LungCell ProliferationGene Expression Regulation, NeoplasticMaleMiceMice, Inbred C57BLNeovascularization, PathologicReceptors, Corticotropin-Releasing HormoneUrocortinsConceptsInhibits tumor growthTumor growthTumor vascularizationActivation of CRFR2Potential therapeutic roleTumor growth inhibitionTumor-suppressing effectsCRFR2 activationMeasurable tumorsTumor cell cyclingCell tumorsTherapeutic roleClinical malignancyUrocortin 2Peripheral tissuesCRFR2Ucn2Genetic deletionTissue vascularityDirect inhibitionVessel diameterCell proliferationVessel numberVascularizationTumors
2004
Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS. Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004, 6: 485-495. PMID: 15542432, DOI: 10.1016/j.ccr.2004.09.026.Peer-Reviewed Original ResearchAnimalsCell HypoxiaCell ProliferationCells, CulturedChemotaxisEndothelial CellsGene Expression RegulationHypoxia-Inducible Factor 1, alpha SubunitMiceNeoplasmsNeovascularization, PathologicTranscription FactorsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2Wound Healing