2012
IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension
Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA, Lee CG. IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2012, 304: l112-l124. PMID: 23125252, PMCID: PMC3543640, DOI: 10.1152/ajplung.00101.2012.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionIL-13Human pulmonary artery smooth muscle cellsDevelopment of PHPulmonary artery smooth muscle cellsRight ventricle systolic pressurePathogenesis of PHArtery smooth muscle cellsExpression of ARG2Pulmonary arterial hypertensionPulmonary vascular remodelingVentricle systolic pressurePotential therapeutic targetIL-13 treatmentSmooth muscle cellsNull mutant miceArterial hypertensionEffector cytokinesMedial thickeningSystolic pressureHemodynamic changesPulmonary arterySmall-interfering RNAVascular remodelingArginase-2
2008
Endothelial Expression of Beta‐1 Integrin Is Required for Embryonic Vascular Patterning and Postnatal Vascular Remodeling
lei L, Liu D, Huang Y, Jovin I, Shai S, Kyriakides T, Ross R, Giordano F. Endothelial Expression of Beta‐1 Integrin Is Required for Embryonic Vascular Patterning and Postnatal Vascular Remodeling. The FASEB Journal 2008, 22: 1122.11-1122.11. DOI: 10.1096/fasebj.22.1_supplement.1122.11.Peer-Reviewed Original ResearchVascular remodelingEndothelial expressionSevere fetal growth retardationFetal growth retardationCre/loxP techniqueAbnormal vascular remodelingSignificant clinical importancePostnatal vascular remodelingΒ1 subunit expressionΒ1 integrinBeta 1 integrinΒ1 integrin expressionBlood flowAdult miceClinical importanceSubunit expressionGlobal deletionPostnatal survivalGrowth retardationEndothelial cellsIntegrin expressionTime pointsHealing woundsSignificant functional effectsFunctional effectsEndothelial Expression of β1 Integrin Is Required for Embryonic Vascular Patterning and Postnatal Vascular Remodeling
Lei L, Liu D, Huang Y, Jovin I, Shai SY, Kyriakides T, Ross RS, Giordano FJ. Endothelial Expression of β1 Integrin Is Required for Embryonic Vascular Patterning and Postnatal Vascular Remodeling. Molecular And Cellular Biology 2008, 28: 794-802. PMID: 17984225, PMCID: PMC2223431, DOI: 10.1128/mcb.00443-07.Peer-Reviewed Original ResearchConceptsVascular patterningBeta1 integrinNormal vascular patterningEmbryonic vascular patterningBeta1 subunit expressionEmbryonic deathDevelopmental time pointsPostnatal vascular remodelingSignificant functional effectsBeta1 integrin expressionBiological processesVascular developmentExpression resultsDiminished vascularizationΒ1 integrinEmbryonic day 5Vascular remodelingCell growthGene deletionBeta1 subunitBeta1 geneIntegrins