2016
Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice
Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC. Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Molecular Medicine 2016, 8: 643-653. PMID: 27137489, PMCID: PMC4888854, DOI: 10.15252/emmm.201506031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisCollagen Type ICollagen Type I, alpha 1 ChainCollagen Type IIIDisease Models, AnimalMiceMicroRNAsConceptsPlaque morphologyReduced lesion sizeAcute myocardial infarctionAtherosclerotic mouse modelVulnerable atherosclerotic lesionsFibrous cap thicknessPlaque extracellular matrixChronic administrationExtracellular matrixAtherosclerotic miceMyocardial infarctionPlaque remodelingSolid organsAbnormal remodelingMouse modelAtherosclerotic lesionsAtherosclerotic plaquesBlood chemistryLesion sizeMiR-29Necrotic zoneLesionsPlaquesCap thicknessMiR-29 target genes
2014
Improved repair of dermal wounds in mice lacking microRNA‐155
van Solingen C, Araldi E, Chamorro‐Jorganes A, Fernández‐Hernando C, Suárez Y. Improved repair of dermal wounds in mice lacking microRNA‐155. Journal Of Cellular And Molecular Medicine 2014, 18: 1104-1112. PMID: 24636235, PMCID: PMC4112003, DOI: 10.1111/jcmm.12255.Peer-Reviewed Original ResearchConceptsMiR-155Wound tissueWound healingIncreased expressionWound closureImpaired wound repairAnalysis of woundsSkin of miceMiR-155 targetsType 1 collagenWild-type animalsInflammatory mediatorsWT miceWound healing processImmune responseInterleukin-4Healthy skinMicroRNA-155Punch woundsMiceElevated numbersBeneficial effectsWound closingDermal wound healingDermal wounds