2013
MicroRNAs as pharmacological targets in endothelial cell function and dysfunction
Chamorro-Jorganes A, Araldi E, Suárez Y. MicroRNAs as pharmacological targets in endothelial cell function and dysfunction. Pharmacological Research 2013, 75: 15-27. PMID: 23603154, PMCID: PMC3752325, DOI: 10.1016/j.phrs.2013.04.002.Peer-Reviewed Original ResearchConceptsEndothelial cell functionShort non-coding RNAsCell functionPost-transcriptional levelNon-coding RNAsEndothelial-specific microRNAsGene expressionMorphogenic capacityCritical regulatorNormal endothelial cell functionMicroRNAsCell dysfunctionEndothelial cell dysfunctionPathophysiological conditionsLatest insightsParacrine mannerPharmacological targetsEndothelial cellsTherapeutic potentialBarrier functionTraffickingRNALeukocyte traffickingRegulatorTarget
2012
Mir-33 regulates cell proliferation and cell cycle progression
Cirera-Salinas D, Pauta M, Allen RM, Salerno AG, Ramírez CM, Chamorro-Jorganes A, Wanschel AC, Lasuncion MA, Morales-Ruiz M, Suarez Y, Baldan A, Esplugues E, Fernández-Hernando C. Mir-33 regulates cell proliferation and cell cycle progression. Cell Cycle 2012, 11: 922-933. PMID: 22333591, PMCID: PMC3323796, DOI: 10.4161/cc.11.5.19421.Peer-Reviewed Original ResearchConceptsCell cycle progressionCyclin-dependent kinase 6Cycle progressionCell proliferationCell cycle regulationMiR-33Expression of genesCyclin D1Cell cycle arrestSREBP genesCycle regulationFatty acid metabolismHost genesPosttranscriptional levelGene expressionIntronic sequencesKinase 6Cellular growthCritical regulatorCycle arrestCellular levelLiver regenerationGenesMiR-33 expressionAcid metabolism