The Clonal Expansion Dynamics of the HIV-1 Reservoir: Mechanisms of Integration Site-Dependent Proliferation and HIV-1 Persistence
Yeh YJ, Yang K, Razmi A, Ho YC. The Clonal Expansion Dynamics of the HIV-1 Reservoir: Mechanisms of Integration Site-Dependent Proliferation and HIV-1 Persistence. Viruses 2021, 13: 1858. PMID: 34578439, PMCID: PMC8473165, DOI: 10.3390/v13091858.Peer-Reviewed Original ResearchConceptsHIV-1-infected cellsHIV-1 latent reservoirAntiretroviral therapyHIV-1Cancer-related gene expressionHIV-1 promoterHIV-1 integration sitesLatent reservoirClonal expansionClonal expansion dynamicsCancer-related genesLong-term suppressive antiretroviral therapyHIV-1 promoter activitySuppressive antiretroviral therapyLow-level viremiaHIV-1 reservoirHIV-1 persistenceHIV-1 transcriptionCertain cancer-related genesViral reboundGene expressionRare caseLoss of functionTherapeutic agentsTumor suppressor geneShock-and-kill versus block-and-lock: Targeting the fluctuating and heterogeneous HIV-1 gene expression
Yeh YJ, Ho YC. Shock-and-kill versus block-and-lock: Targeting the fluctuating and heterogeneous HIV-1 gene expression. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2103692118. PMID: 33758027, PMCID: PMC8072369, DOI: 10.1073/pnas.2103692118.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsGene ExpressionGene Expression Regulation, ViralHIV InfectionsHIV-1HumansVirus ActivationVirus Latency