2023
Combination Therapy of Low-dose Steroids, Tacrolimus and Mycophenolate Mofetil in Primary Membranous Nephropathy: A Single-center Retrospective Cohort Study
Zhao S, Jia L, Cui C, Chen Z, Duan Z, Gao J, Wei L, Xue X, Lei F, Yang Y, Liu J, Xu P, Wang R, Wei Y, Tian X, Fu R. Combination Therapy of Low-dose Steroids, Tacrolimus and Mycophenolate Mofetil in Primary Membranous Nephropathy: A Single-center Retrospective Cohort Study. Integrative Medicine In Nephrology And Andrology 2023, 10: e00012. DOI: 10.1097/imna-d-22-00012.Peer-Reviewed Original ResearchPrimary membranous nephropathyIntravenous cyclophosphamideRegimen groupMycophenolate mofetilMembranous nephropathyNephrotic syndromeCombination therapyBiopsy-proven primary membranous nephropathySingle-center retrospective cohort studyPC groupCumulative complete remission ratesLow-dose glucocorticoidsLow-dose steroidsNon-inferior efficacyRetrospective cohort studySerum creatinine levelsComplete remission rateCommon pathological typeUrinary protein levelsFavorable safety profileBest combination therapyAlternative treatment choiceRemission rateAdverse eventsCohort study
2019
Podocyte histone deacetylase activity regulates murine and human glomerular diseases
Inoue K, Gan G, Ciarleglio M, Zhang Y, Tian X, Pedigo CE, Cavanaugh C, Tate J, Wang Y, Cross E, Groener M, Chai N, Wang Z, Justice A, Zhang Z, Parikh CR, Wilson FP, Ishibe S. Podocyte histone deacetylase activity regulates murine and human glomerular diseases. Journal Of Clinical Investigation 2019, 129: 1295-1313. PMID: 30776024, PMCID: PMC6391095, DOI: 10.1172/jci124030.Peer-Reviewed Original ResearchConceptsEarly growth response 1Histone deacetylase 1Proteinuric patientsKidney diseaseHDAC2 activityValproic acidVeterans Aging Cohort StudyEnd-stage kidney diseaseDegree of proteinuriaGlomerular filtration rateAging Cohort StudyInhibition of HDAC1Proteinuric kidney diseaseHuman glomerular diseasesGlomerular disease modelsConnectivity Map databaseCohort studyFiltration rateGlomerular diseaseHistone deacetylase activityProteinuric kidneysHDAC inhibitorsProteinuriaMRNA expressionGenetic ablation