Xuefei Tian, MD
Research ScientistCards
About
Research
Publications
2024
Efficacy and Safety of Belimumab in Severe Lupus Nephritis: A Retrospective Single-Center Study
Aierken A, Zhuang J, Yang S, Yalikun D, Xu C, Zhang C, Tian X, Jiang H. Efficacy and Safety of Belimumab in Severe Lupus Nephritis: A Retrospective Single-Center Study. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.202486qykah2. DOI: 10.1681/asn.202486qykah2.Peer-Reviewed Original ResearchAtypical Hemolytic Uremic Syndrome with Peripheral Gangrene
Aierken A, Muhetaer G, Yang S, Zhuang J, Jiang H, Tian X. Atypical Hemolytic Uremic Syndrome with Peripheral Gangrene. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.20244hj831a8. DOI: 10.1681/asn.20244hj831a8.Peer-Reviewed Original ResearchPodocytic Infolding Glomerulopathy: A Systematic Report of 44 Cases
Shen Z, Zhang C, Zhuang J, Qu Y, Tian X, Jiang H. Podocytic Infolding Glomerulopathy: A Systematic Report of 44 Cases. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024y382k1hb. DOI: 10.1681/asn.2024y382k1hb.Peer-Reviewed Original ResearchWIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury
Wang Y, Cui C, Zhao W, Tian X, Liu P, Wei L, Zhu Z, Liu M, Fu R, Jia L. WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury. Immunobiology 2024, 229: 152832. PMID: 38943814, DOI: 10.1016/j.imbio.2024.152832.Peer-Reviewed Original ResearchAcute kidney injuryAcute tubular injuryLPS-induced acute kidney injuryHuman kidney 2Wip1 activityKidney injuryRenal tubulesUnilateral ischemia-reperfusion injurySepsis-associated acute kidney injuryRenal tubules of patientsHK2 cellsProtein levelsInduce acute injuryProximal renal tubulesWild-type p53-induced phosphatase 1Ischemia-reperfusion injuryPhosphorylation of p38 MAPKGSDMD-NHuman kidney-2 cellsSingle-cell sequencingPPM1D mRNAPhospho-p38 MAPKTubular injuryWip1 inhibitorScRNA-seqFallopian tube wrapping as a cause of catheter malfunction in peritoneal dialysis: a report of two cases and management strategies.
Chen X, Chen Z, Du Y, Tian X, Fu R. Fallopian tube wrapping as a cause of catheter malfunction in peritoneal dialysis: a report of two cases and management strategies. AME Case Rep 2024, 8: 66. PMID: 39091550, DOI: 10.21037/acr-23-201.Peer-Reviewed Case Reports and Technical NotesClinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study
Ha X, Zhao Z, Zhao T, Muhetaer G, Wang X, Bao A, Duan Y, Zhuang J, Song X, Zhou Y, Zhang Q, Wu J, Fan M, Zhang L, Tian X, Jiang H. Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study. Integrative Medicine In Nephrology And Andrology 2024, 11: e23-00018. DOI: 10.1097/imna-d-23-00018.Peer-Reviewed Original ResearchSARS-CoV-2 Omicron infectionMaintenance hemodialysisClinical characteristicsMHD patientsSARS-CoV-2 Omicron variantSARS-CoV-2Disease severityFollow-upSerum C-reactive protein levelsOmicron infectionRisk factorsC-reactive protein levelsFollow-up assessmentIndependent risk factorSpectrum of disease severityChinese adult patientsTailored treatment strategiesNegative nucleic acidAdult MHD patientsMaintenance hemodialysis patientsHigh-risk populationArterial oxygen partial pressureOmicron variantProcalcitonin levelsPrognostic factorsZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging
Jiang Q, Song G, He L, Li X, Jiang B, Wang Q, Wang S, Kim C, Barkestani M, Lopez R, Fan M, Wanniarachchi K, Quaranta M, Tian X, Mani A, Gonzalez A, Goodwin J, Sessa W, Ishibe S, Jane-Wit D. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging. Kidney International 2024, 106: 419-432. PMID: 38797325, PMCID: PMC11343665, DOI: 10.1016/j.kint.2024.05.007.Peer-Reviewed Original ResearchVascular barrier functionEndothelial cellsReduced endothelial nitric oxideRegulator of vascular barrier functionEndothelial nitric oxide signalingENOS activityEndosome-associated proteinsBarrier functionKidney organ culturesEndothelial nitric oxideAkt-dependent mannerNitric oxide donorGTPase Rab5Nitric oxide signalingZFYVE21Live cell imagingKidney insufficiencyReporter miceTrafficking mechanismsAccelerated aging phenotypeKnockout miceInterstitial edemaKidney functionVesicular populationOxide donorMediating role of social support in dysphoria, despondency, and quality of life in patients undergoing maintenance hemodialysis
Zhou X, Jiang H, Zhou Y, Wang X, Ren H, Tian X, Zhang Q. Mediating role of social support in dysphoria, despondency, and quality of life in patients undergoing maintenance hemodialysis. World Journal Of Psychiatry 2024, 14: 409-420. PMID: 38617988, PMCID: PMC11008395, DOI: 10.5498/wjp.v14.i3.409.Peer-Reviewed Original ResearchQuality of lifeSocial supportSocial Support Rating ScaleMental well-being of patientsLevels of social supportOveral quality of lifeImpact of social supportSelf-Rating Anxiety ScaleQuality of Life ScaleSelf-Rating Depression ScaleWell-being of patientsSelf-ratingsMental well-beingQuality of life of patientsDepression ScaleEffects of dysphoriaPsychological issuesAnxiety ScaleRating ScaleDysphoriaMaintenance hemodialysisMediation roleRandom sampling approachSupportDespondencyDPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways
Li K, Zhang Y, Zhao W, Wang R, Li Y, Wei L, Wang L, Chen X, Chen Z, Liu P, Nie N, Tian X, Fu R. DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways. Toxicology Letters 2024, 395: 1-10. PMID: 38458339, DOI: 10.1016/j.toxlet.2024.03.001.Peer-Reviewed Original ResearchHuman mesangial cellsAkt signaling pathwayExtracellular matrixSignaling pathwayDipeptidyl peptidase IVMesangial cellsExpression of ECM-related proteinsPhosphorylation of AktECM-related proteinsAbnormal extracellular matrixECM depositionExcessive deposition of extracellular matrixPhosphorylation of Smad2DPP8/9 inhibitionDeposition of extracellular matrixGlomerular mesangial cellsDPP9Collagen IVDPP8AktMultiple diseasesDPP8/9SiRNAPathogenesis of glomerular diseaseCellsA comparison of chemiluminescent immunoassay and enzyme-linked immunosorbent assay for detecting phospholipase A2 receptor antibody in primary membranous nephropathy
Ma X, Wang R, Wei L, Liu P, Jing L, Wang J, Dong W, Tian X, Fu R. A comparison of chemiluminescent immunoassay and enzyme-linked immunosorbent assay for detecting phospholipase A2 receptor antibody in primary membranous nephropathy. Practical Laboratory Medicine 2024, 39: e00385. PMID: 38495349, PMCID: PMC10940994, DOI: 10.1016/j.plabm.2024.e00385.Peer-Reviewed Original ResearchAnti-PLA2R antibodiesEnzyme-linked immunosorbent assayNegative predictive valuePositive predictive valueAnti-PLA2RMembranous nephropathyChemiluminescence immunoassayLevels of anti-PLA2R antibodiesPhospholipase A2 receptor antibodyPredictive valuePrimary membranous nephropathyPhospholipase A2 receptorImmunosorbent assayResults Serum levelsStatistical analysis of sensitivityROC curve analysisNon-membranous nephropathyStatistically significant differencePMN groupReceptor antibodiesSerum levelsA2 receptorsSpearman correlation analysisDiagnostic valueNephropathy
Academic Achievements & Community Involvement
News
News
- January 11, 2023
Discoveries & Impact (January 2023)
- November 02, 2022
ASN Kidney Week 2022: Presentations from Yale Nephrology
- February 16, 2022
Discoveries & Impact (February 2022)