Signaling through the Adaptor Molecule MyD88 in CD4+ T Cells Is Required to Overcome Suppression by Regulatory T Cells
Schenten D, Nish SA, Yu S, Yan X, Lee HK, Brodsky I, Pasman L, Yordy B, Wunderlich FT, Brüning JC, Zhao H, Medzhitov R. Signaling through the Adaptor Molecule MyD88 in CD4+ T Cells Is Required to Overcome Suppression by Regulatory T Cells. Immunity 2014, 40: 78-90. PMID: 24439266, PMCID: PMC4445716, DOI: 10.1016/j.immuni.2013.10.023.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsCells, CulturedImmunity, InnateImmunologic MemoryImmunosuppression TherapyInterleukin-1Interleukin-18MiceMice, Inbred C57BLMice, TransgenicMyeloid Differentiation Factor 88Organ SpecificityReceptors, Interleukin-1Signal TransductionT-Lymphocytes, RegulatoryTh1 CellsTh17 CellsConceptsToll-like receptorsTh1 cell responsesT cellsCell-specific ablationCell responsesIL-1Interleukin-1 receptor family memberT helper 17 (Th17) cell responsesTreg cell-mediated suppressionTreg cell-specific ablationT cell-specific ablationRegulatory T cellsT regulatory (Treg) cellsCell-mediated suppressionMemory T cellsAdaptor molecule MyD88Adaptive immune responsesIL-1 actsTreg cellsRegulatory cellsReceptor family membersMolecule MyD88Th1 cellsImmune responseMyD88